GPx, MDA, depression and risk of recurrence of stable coronary heart disease

Research output: Contribution to conferenceAbstractpeer-review

Abstract

The aim of the study was to investigate the relationships between oxidative stress (OS) level, depression (D) and risk of recurrence of Stable Coronary Heart Disease (SCHD). A retrospective study was conducted on 174 participants, at the aged 45+ years old : 86 in- patients of the cardiology department with a recurrent SCHD and 88 in-patients of the cardiology department of the with a primary SCHD. The severity of depressive symptoms was assessed using the long 30-item form of Geriatric Depression Scale (GDS), valid Latvian version of GDS-LAT. From each patient were taken the blood samples to measure oxidative stress parameters Malondialdehyde (MDA) and Glutathione Peroxidase (GPx). 83.9% of the sample had high level of MDA. In 72.4% of the sample the GPx level was normal, in 17.8% it was high and in 9.8% - low.  More than a half of the patients are experiencing a D (44.3% - mild D and 6.9% - severe D). GPx was found statistically differing between primary and recurrent SCHD (p=0,003). Patients with both D and high GPx had 10.6 times higher chances of recurrent SHCD compared to those without D and normal GPx. Patients with present D had high levels of MDA and GPx – more often than responders with no D, but this wasn’t statistically significant (p=0.51).:  It could be supposed that GPx is more significant marker of risk of D and recurrence of SCHD. It was significantly higher in depressed patients with recurrent SCHD comparing to patients without D and to patients with primary SCHD and patients with both D and high GPx had higher chances of recurrent SHCD compared to those without D and normal GPx. The high level of MDA in most of both groups patients could evidence that increased OS is a risk factor for CHD in general. 
Original languageEnglish
Pages440
Publication statusPublished - 24 Mar 2021
EventRSU Research week 2021: Knowledge for Use in Practice - Rīga, Latvia
Duration: 24 Mar 202126 Mar 2021
https://rw2021.rsu.lv/conferences/knowledge-use-practice

Conference

ConferenceRSU Research week 2021: Knowledge for Use in Practice
Abbreviated titleRW2021
Country/TerritoryLatvia
CityRīga
Period24/03/2126/03/21
Internet address

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 3.4. Other publications in conference proceedings (including local)

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