The aim of the study was to investigate the relationships between oxidative stress (OS) level, depression (D) and risk of recurrence of Stable Coronary Heart Disease (SCHD). A retrospective study was conducted on 174 participants, at the aged 45+ years old : 86 in- patients of the cardiology department with a recurrent SCHD and 88 in-patients of the cardiology department of the with a primary SCHD. The severity of depressive symptoms was assessed using the long 30-item form of Geriatric Depression Scale (GDS), valid Latvian version of GDS-LAT. From each patient were taken the blood samples to measure oxidative stress parameters Malondialdehyde (MDA) and Glutathione Peroxidase (GPx). 83.9% of the sample had high level of MDA. In 72.4% of the sample the GPx level was normal, in 17.8% it was high and in 9.8% - low. More than a half of the patients are experiencing a D (44.3% - mild D and 6.9% - severe D). GPx was found statistically differing between primary and recurrent SCHD (p=0,003). Patients with both D and high GPx had 10.6 times higher chances of recurrent SHCD compared to those without D and normal GPx. Patients with present D had high levels of MDA and GPx – more often than responders with no D, but this wasn’t statistically significant (p=0.51).: It could be supposed that GPx is more significant marker of risk of D and recurrence of SCHD. It was significantly higher in depressed patients with recurrent SCHD comparing to patients without D and to patients with primary SCHD and patients with both D and high GPx had higher chances of recurrent SHCD compared to those without D and normal GPx. The high level of MDA in most of both groups patients could evidence that increased OS is a risk factor for CHD in general.
- 3.4. Other publications in conference proceedings (including local)