GPx, MDA, depression and risk of recurrence of stable coronary heart disease

The aim of the study was to investigate the relationships between oxidative stress (OS) level, depression (D) and risk of recurrence of Stable Coronary Heart Disease (SCHD). A retrospective study was conducted on 174 participants, at the aged 45+ years old : 86 in- patients of the cardiology department with a recurrent SCHD and 88 in-patients of the cardiology department of the with a primary SCHD. The severity of depressive symptoms was assessed using the long 30-item form of Geriatric Depression Scale (GDS), valid Latvian version of GDS-LAT. From each patient were taken the blood samples to measure oxidative stress parameters Malondialdehyde (MDA) and Glutathione Peroxidase (GPx). 83.9% of the sample had high level of MDA. In 72.4% of the sample the GPx level was normal, in 17.8% it was high and in 9.8% - low.  More than a half of the patients are experiencing a D (44.3% - mild D and 6.9% - severe D). GPx was found statistically differing between primary and recurrent SCHD (p=0,003). Patients with both D and high GPx had 10.6 times higher chances of recurrent SHCD compared to those without D and normal GPx. Patients with present D had high levels of MDA and GPx – more often than responders with no D, but this wasn’t statistically significant (p=0.51).:  It could be supposed that GPx is more significant marker of risk of D and recurrence of SCHD. It was significantly higher in depressed patients with recurrent SCHD comparing to patients without D and to patients with primary SCHD and patients with both D and high GPx had higher chances of recurrent SHCD compared to those without D and normal GPx. The high level of MDA in most of both groups patients could evidence that increased OS is a risk factor for CHD in general.