Graft detachment and rebubbling rate in Descemet membrane endothelial keratoplasty

Mohit Parekh, Pia Leon, Alessandro Ruzza, Davide Borroni, Stefano Ferrari, Diego Ponzin, Vito Romano

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Descemet membrane endothelial keratoplasty (DMEK) is a selective replacement of dysfunctional endothelium with healthy donor Descemet membrane and endothelium. Although the donor preparation and surgical methods still remain a challenge, DMEK is gaining popularity in terms of early rehabilitation and visual outcomes. New and improved donor preparation techniques like prestripped DMEK tissues are being taken up rapidly because of less manipulation that is required in the surgical theatre. Donor graft delivery in the recipient eye has also been improved because of new products like prestripped and preloaded membranes. As DMEK is at its budding stage, only early outcomes have been known so far. Early graft detachment, rebubbling rates, and primary failures are still being studied in DMEK. As there are different techniques that are currently used for preparation and injection of the graft, it becomes difficult to judge the results based on specific inclusion and exclusion criteria. Graft detachment and rebubbling rates have been a huge challenge both during the surgery and also while reporting postoperative data. We highlight the importance of defining graft detachment and rebubbling rates and their surgical relevance, which may also have an impact on graft preparation and insertion techniques.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalSurvey of Ophthalmology
Issue number2
Publication statusPublished - 1 Mar 2018


  • DMEK
  • graft detachment
  • rebubble rate

Field of Science*

  • 1.6 Biological sciences
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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