Gray values of the cervical vertebrae detected by cone beam computed tomography for the identification of osteoporosis and osteopenia in postmenopausal women

OBJECTIVES: This study aimed to determine whether the gray values (GVs) of the second and third cervical vertebrae in cone beam computed tomography (CBCT) are affected by general bone mineral density (BMD) in postmenopausal women and to evaluate whether CBCT can be used for predicting the risk of osteoporosis.

STUDY DESIGN: The present cross-sectional study included 127 edentulous postmenopausal women (average age, 70.4 ± 8.9 years) who underwent CBCT examinations. BMD measurements of the lumbar spine and both femoral necks were performed by dual-energy x-ray absorptiometry. The CBCT images were analyzed with OnDemand3D Dental software. GVs of the axial and sagittal sections of the cervical second and third vertebral bodies were obtained.

RESULTS: The GVs of the second and third cervical vertebrae decreased significantly with decreasing BMD. The axial GV of the second cervical vertebra showed the highest sensitivity (80.6%), highest negative predictive value (89.0%), lowest negative likelihood ratio (0.39), and highest area under the curve value (0.68) to predict osteoporosis.

CONCLUSIONS: Women with reduced BMD have lower GVs for the second and third cervical vertebrae. Changes in the GV of the second vertebra can potentially be used to determine the risk of osteoporosis in postmenopausal women.