Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia

Irina Sominskaya; Marija Mihailova; Juris Jansons; Viktorija Emelyanova; Inese Folkmane; Eriks Smagris; Uga Dumpis; Rafails Rozentals; Paul Pumpens

doi:10.1159/000081748

Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia

Irina Sominskaya, Marija Mihailova, Juris Jansons, Viktorija Emelyanova, Inese Folkmane, Eriks Smagris, Uga Dumpis, Rafails Rozentals, Paul Pumpens

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The incidence of genome variants of hepatitis B and hepatitis C viruses among 38 long-term (2-15 years) immunosuppressed patients after renal transplantation and 10 patients undergoing dialysis was investigated. Twelve patients had only HBV infection, 9 had only HCV infection and 14 were co-infected. Regions corresponding to the HBV X/EnII/BCP, preC/C, preS/S and to the HCV core were sequenced for molecular characterization of the HBV and HCV genomes. Fifty-seven percent of HBV DNA isolates belonged to genotype D and 42% to genotype A, whereas 77% of HCV RNA isolates belonged to genotype 1b and only 17% to genotype 3a. One sample (6%) was of genotype 2c. Detailed analysis of the above-mentioned HBV genome regions revealed the presence of nucleotide point mutations, which, in some cases, resulted in amino acid substitutions. The clinical significance of such mutations is discussed.

Original language	English
Pages (from-to)	192-200
Number of pages	9
Journal	Intervirology
Volume	48
Issue number	2-3
DOIs	https://doi.org/10.1159/000081748
Publication status	Published - Mar 2005
Externally published	Yes

Keywords*

Genotype
Hepatitis B virus
Hepatitis C virus
Mutation
Subtypes
Variant

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000081748

https://www-proquest-com.db.rsu.lv/docview/67711068?pq-origsite=primo

Cite this

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title = "Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia",

abstract = "The incidence of genome variants of hepatitis B and hepatitis C viruses among 38 long-term (2-15 years) immunosuppressed patients after renal transplantation and 10 patients undergoing dialysis was investigated. Twelve patients had only HBV infection, 9 had only HCV infection and 14 were co-infected. Regions corresponding to the HBV X/EnII/BCP, preC/C, preS/S and to the HCV core were sequenced for molecular characterization of the HBV and HCV genomes. Fifty-seven percent of HBV DNA isolates belonged to genotype D and 42% to genotype A, whereas 77% of HCV RNA isolates belonged to genotype 1b and only 17% to genotype 3a. One sample (6%) was of genotype 2c. Detailed analysis of the above-mentioned HBV genome regions revealed the presence of nucleotide point mutations, which, in some cases, resulted in amino acid substitutions. The clinical significance of such mutations is discussed.",

keywords = "Genotype, Hepatitis B virus, Hepatitis C virus, Mutation, Subtypes, Variant",

author = "Irina Sominskaya and Marija Mihailova and Juris Jansons and Viktorija Emelyanova and Inese Folkmane and Eriks Smagris and Uga Dumpis and Rafails Rozentals and Paul Pumpens",

year = "2005",

month = mar,

doi = "10.1159/000081748",

language = "English",

volume = "48",

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journal = "Intervirology",

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TY - JOUR

T1 - Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia

AU - Sominskaya, Irina

AU - Mihailova, Marija

AU - Jansons, Juris

AU - Emelyanova, Viktorija

AU - Folkmane, Inese

AU - Smagris, Eriks

AU - Dumpis, Uga

AU - Rozentals, Rafails

AU - Pumpens, Paul

PY - 2005/3

Y1 - 2005/3

N2 - The incidence of genome variants of hepatitis B and hepatitis C viruses among 38 long-term (2-15 years) immunosuppressed patients after renal transplantation and 10 patients undergoing dialysis was investigated. Twelve patients had only HBV infection, 9 had only HCV infection and 14 were co-infected. Regions corresponding to the HBV X/EnII/BCP, preC/C, preS/S and to the HCV core were sequenced for molecular characterization of the HBV and HCV genomes. Fifty-seven percent of HBV DNA isolates belonged to genotype D and 42% to genotype A, whereas 77% of HCV RNA isolates belonged to genotype 1b and only 17% to genotype 3a. One sample (6%) was of genotype 2c. Detailed analysis of the above-mentioned HBV genome regions revealed the presence of nucleotide point mutations, which, in some cases, resulted in amino acid substitutions. The clinical significance of such mutations is discussed.

AB - The incidence of genome variants of hepatitis B and hepatitis C viruses among 38 long-term (2-15 years) immunosuppressed patients after renal transplantation and 10 patients undergoing dialysis was investigated. Twelve patients had only HBV infection, 9 had only HCV infection and 14 were co-infected. Regions corresponding to the HBV X/EnII/BCP, preC/C, preS/S and to the HCV core were sequenced for molecular characterization of the HBV and HCV genomes. Fifty-seven percent of HBV DNA isolates belonged to genotype D and 42% to genotype A, whereas 77% of HCV RNA isolates belonged to genotype 1b and only 17% to genotype 3a. One sample (6%) was of genotype 2c. Detailed analysis of the above-mentioned HBV genome regions revealed the presence of nucleotide point mutations, which, in some cases, resulted in amino acid substitutions. The clinical significance of such mutations is discussed.

KW - Genotype

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Mutation

KW - Subtypes

KW - Variant

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U2 - 10.1159/000081748

DO - 10.1159/000081748

M3 - Article

C2 - 15812194

AN - SCOPUS:23844499780

SN - 0300-5526

VL - 48

SP - 192

EP - 200

JO - Intervirology

JF - Intervirology

IS - 2-3

ER -

Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

Access to Document

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