Hepatitis B and C virus variants in long-term immunosuppressed renal transplant patients in Latvia

Irina Sominskaya, Marija Mihailova, Juris Jansons, Viktorija Emelyanova, Inese Folkmane, Eriks Smagris, Uga Dumpis, Rafails Rozentals, Paul Pumpens

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The incidence of genome variants of hepatitis B and hepatitis C viruses among 38 long-term (2-15 years) immunosuppressed patients after renal transplantation and 10 patients undergoing dialysis was investigated. Twelve patients had only HBV infection, 9 had only HCV infection and 14 were co-infected. Regions corresponding to the HBV X/EnII/BCP, preC/C, preS/S and to the HCV core were sequenced for molecular characterization of the HBV and HCV genomes. Fifty-seven percent of HBV DNA isolates belonged to genotype D and 42% to genotype A, whereas 77% of HCV RNA isolates belonged to genotype 1b and only 17% to genotype 3a. One sample (6%) was of genotype 2c. Detailed analysis of the above-mentioned HBV genome regions revealed the presence of nucleotide point mutations, which, in some cases, resulted in amino acid substitutions. The clinical significance of such mutations is discussed.

Original languageEnglish
Pages (from-to)192-200
Number of pages9
Issue number2-3
Publication statusPublished - Mar 2005
Externally publishedYes


  • Genotype
  • Hepatitis B virus
  • Hepatitis C virus
  • Mutation
  • Subtypes
  • Variant

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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