High consumption of fatty fish from the Baltic Sea is associated with changes in human lymphocyte subset levels

Lars Hagmar, Torgny Hallberg, Marcis Leja, Anita Nilsson, Andrejs Schütz

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Fatty fish from the Baltic Sea accumulate immunotoxic persistent organochlorine compounds. In a previous study we found inverse correlations between such fish consumption and natural killer (NK) cell levels in a Swedish population. The present study concerns 68 Latvian subjects with high, low or intermediate fish consumption. High fish consumption correlated positively with B cell levels and CD4+/CD8+ ratios, but negatively with levels of cytotoxic (CD8+) T cells. Furthermore, NK cell levels correlated inversely with plasma selenium, one of several strong correlates with fish intake. A high fish diet includes a set of possible immunomodulating agents. It is presently not possible to pinpoint the cause for the observed subset deviations or to establish their possible biological importance.

Original languageEnglish
Pages (from-to)335-342
Number of pages8
JournalToxicology Letters
Volume77
Issue number1-3
DOIs
Publication statusPublished - May 1995
Externally publishedYes

Keywords

  • B-lymphocytes
  • CD4+ CD8+ ratio
  • Dioxins
  • Fish
  • Natural killer cells
  • PCBs
  • Selenium

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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