High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol

Elzbieta Maria Buczkowska; Kirils Kukuls; Zoltan Mark Horvath; Alīna Jaroslava Frolova; Līga Pētersone; Suha Dadou; Valentyn Mohylyuk

doi:10.13140/RG.2.2.36011.40489

High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol

Elzbieta Maria Buczkowska
, Kirils Kukuls
, Zoltan Mark Horvath
, Alīna Jaroslava Frolova
, Līga Pētersone
, Suha Dadou
, Valentyn Mohylyuk (Corresponding Author)

Lead Researcher Group

Research output: Contribution to conference › Poster › peer-review

Original language	English
DOIs	https://doi.org/10.13140/RG.2.2.36011.40489
Publication status	Published - 26 Mar 2026
Event	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - Prague Congress Centre, Prague, Czech Republic Duration: 23 Mar 2026 → 26 Mar 2026 Conference number: 15 https://worldmeeting.org/

Meeting

Meeting	15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Abbreviated title	PBP World meeting
Country/Territory	Czech Republic
City	Prague
Period	23/03/26 → 26/03/26
Internet address	https://worldmeeting.org/

Keywords*

solid dosage forms
oral dosage forms
immediate-release
tablets
high-drug-loaded
twin-screw melt granulation
mannitol
caffeine
granulation
continuous
manufacturing
mechanical properties
tensile strength

Field of Science*

1.4 Chemical sciences
2.4 Chemical engineering
2.5 Materials engineering
3.1 Basic medicine

Publication Type*

3.4. Other publications in conference proceedings (including local)

Access to Document

10.13140/RG.2.2.36011.40489Licence: CC BY

5 Poster
2 Article

Difference in Tableting of Lubricated Spray-Dried Mannitol and Fluid-Bed Granulated Isomalt
Mohylyuk, V. (Corresponding Author), Kukuls, K., Frolova, A. J., Horvath, Z. M., Kolisnyk, T., Buczkowska, E. M., Pētersone, L. & Pelloux, A., Dec 2025, In: Pharmaceutics. 17, 12, 1566.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

1 Downloads (Pure)
Eutectic mixtures with choline chloride and polyols: Solubility enhancement of ibuprofen in aqueous solutions
Pētersone, L. (Corresponding Author), Mahinovs, R., Gurkina, K. & Mohylyuk, V., Oct 2025. 1 p.
Research output: Contribution to conference › Poster
Polyols as a sustainable solution in oral drug delivery systems
Buczkowska, E. M., Horvath, Z. M., Kukuls, K., Frolova, A. J., Pētersone, L. (Corresponding Author) & Mohylyuk, V., 26 Sept 2025.
Research output: Contribution to conference › Poster

Open Access
File

5 Downloads (Pure)

1 Finished

Suitability of sugar alcohols (polyols) as binders in twin-screw melt granulation for preparation of high-drug-loaded immediate-release tablets with superior mechanical properties
Mohylyuk, V. (Project leader), Buczkowska, E. M. (Leading expert), Pētersone, L. (Leading expert), Žogota, M. (Expert), Horvath, Z. M. (Participant), Kukuls, K. (Participant) & Frolova, A. J. (Participant)
European Commission
1/04/24 → 31/03/26
Project: Consolidation grants

BET Surface Area, Pore Volume, and Pore Size Distribution of Polyols
Horvath, Z. M. (Creator), Frolova, A. J. (Creator), Kukuls, K. (Creator), Gniazdowska, E. M. (Creator), Pētersone, L. (Creator), Mohylyuk, V. (Creator) & Buczkowska, E. M. (Creator), Rīga Stradiņš University Institutional Repository Dataverse, 29 Sept 2025
DOI: 10.48510/fk2/96wykv, https://doi.org/10.48510/FK2/96WYKV
Dataset
Karl Fischer (KF) Titration of Polyols
Frolova, A. J. (Creator), Kukuls, K. (Creator), Horvath, Z. M. (Creator), Gniazdowska, E. M. (Creator), Pētersone, L. (Creator), Mohylyuk, V. (Creator) & Buczkowska, E. M. (Creator), Rīga Stradiņš University Institutional Repository Dataverse, 17 Mar 2025
DOI: 10.48510/fk2/4areio, https://doi.org/10.48510/FK2/4AREIO and one more link, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/4AREIO (show fewer)
Dataset
Optical Microscopy of Polyols
Kukuls, K. (Creator), Frolova, A. J. (Creator), Horvath, Z. M. (Creator), Gniazdowska, E. M. (Creator) & Mohylyuk, V. (Creator), Rīga Stradiņš University Institutional Repository Dataverse, 22 Jan 2025
DOI: 10.48510/FK2/RBPONG, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/RBPONG
Dataset

2 Oral presentation
2 Poster presentation
1 Participating in a conference, workshop, ...

Modern trends in the development of dosage form formulations: a view through the prism of publications by the specific scientific group
Mohylyuk, V. (Speaker)
15 Apr 2026
Activity: Talk or presentation types › Oral presentation
High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol
Buczkowska, E. M. (Speaker), Kukuls, K. (Co-author), Horvath, Z. M. (Co-author), Frolova, A. J. (Co-author), Pētersone, L. (Co-author) & Mohylyuk, V. (Co-author)
23 Mar 2026 → 26 Mar 2026
Activity: Talk or presentation types › Poster presentation
15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Horvath, Z. M. (Participant)
23 Mar 2026 → 26 Mar 2026
Activity: Participating in or organising an event types › Participating in a conference, workshop, ...

File

High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol
Buczkowska, E. M., Kukuls, K., Horvath, Z. M., Frolova, A. J., Pētersone, L., Dadou, S. & Mohylyuk, V.
13/04/26
1 item of Media coverage
Press/Media

Cite this

Buczkowska, E. M., Kukuls, K., Horvath, Z. M., Frolova, A. J., Pētersone, L., Dadou, S., & Mohylyuk, V. (2026). High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic. https://doi.org/10.13140/RG.2.2.36011.40489

@conference{031787407daf4530936fb37acbdcb919,

title = "High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol",

keywords = "solid dosage forms, oral dosage forms, immediate-release, tablets, high-drug-loaded, twin-screw melt granulation, mannitol, caffeine, granulation, continuous, manufacturing, mechanical properties, tensile strength",

author = "Buczkowska, \{Elzbieta Maria\} and Kirils Kukuls and Horvath, \{Zoltan Mark\} and Frolova, \{Alīna Jaroslava\} and Līga Pētersone and Suha Dadou and Valentyn Mohylyuk",

year = "2026",

month = mar,

day = "26",

doi = "10.13140/RG.2.2.36011.40489",

language = "English",

note = "15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, PBP World meeting ; Conference date: 23-03-2026 Through 26-03-2026",

url = "https://worldmeeting.org/",

}

Buczkowska, EM, Kukuls, K , Horvath, ZM, Frolova, AJ, Pētersone, L, Dadou, S & Mohylyuk, V 2026, 'High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol', 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic, 23/03/26 - 26/03/26. https://doi.org/10.13140/RG.2.2.36011.40489

High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol. / Buczkowska, Elzbieta Maria; Kukuls, Kirils ; Horvath, Zoltan Mark et al.
2026. Poster session presented at 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Prague, Czech Republic.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol

AU - Buczkowska, Elzbieta Maria

AU - Kukuls, Kirils

AU - Horvath, Zoltan Mark

AU - Frolova, Alīna Jaroslava

AU - Pētersone, Līga

AU - Dadou, Suha

AU - Mohylyuk, Valentyn

N1 - Conference code: 15

PY - 2026/3/26

Y1 - 2026/3/26

KW - solid dosage forms

KW - oral dosage forms

KW - immediate-release

KW - tablets

KW - high-drug-loaded

KW - twin-screw melt granulation

KW - mannitol

KW - caffeine

KW - granulation

KW - continuous

KW - manufacturing

KW - mechanical properties

KW - tensile strength

U2 - 10.13140/RG.2.2.36011.40489

DO - 10.13140/RG.2.2.36011.40489

M3 - Poster

T2 - 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Y2 - 23 March 2026 through 26 March 2026

ER -

High-drug-loaded immediate-release tablets of caffeine prepared by twin-screw melt granulation with mannitol

Meeting

Keywords*

Field of Science*

Publication Type*

Access to Document

Research output

Projects

Datasets

Activities

Press/Media

Cite this