High expression of gli1 is associated with better survival in advanced sclc

V. Kozirovskis; E. Zandberga; M. Magone; G. Purkalne; A. Line; U. Vikmanis

doi:10.32471/exp-oncology.2312-8852.vol-42-no-1.14266

High expression of gli1 is associated with better survival in advanced sclc

V. Kozirovskis (Corresponding Author), E. Zandberga, M. Magone, G. Purkalne, A. Line, U. Vikmanis

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

AIM: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival.

MATERIALS AND METHODS: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor's samples (stratified by median survival, independent samples t-test).

RESULTS: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor's biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test).

CONCLUSION: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study.

Original language	English
Pages (from-to)	75-77
Number of pages	3
Journal	Experimental Oncology
Volume	42
Issue number	1
DOIs	https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-1.14266
Publication status	Published - Mar 2020
Externally published	Yes

Keywords*

GLI1
prognosis
small cell lung cancer
Sonic hedgehog pathway
survival

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.32471/exp-oncology.2312-8852.vol-42-no-1.14266

Cite this

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title = "High expression of gli1 is associated with better survival in advanced sclc",

abstract = "AIM: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival.MATERIALS AND METHODS: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor's samples (stratified by median survival, independent samples t-test).RESULTS: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor's biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test).CONCLUSION: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study.",

keywords = "GLI1, prognosis, small cell lung cancer, Sonic hedgehog pathway, survival",

author = "V. Kozirovskis and E. Zandberga and M. Magone and G. Purkalne and A. Line and U. Vikmanis",

note = "Funding Information: This work was supported by the Latvian National Research Programme BIOMEDICINE 2014–2017. Publisher Copyright: {\textcopyright} 2020 Morion LLC. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = mar,

doi = "10.32471/exp-oncology.2312-8852.vol-42-no-1.14266",

language = "English",

volume = "42",

pages = "75--77",

journal = "Experimental Oncology",

issn = "1812-9269",

publisher = "Morion LLC",

number = "1",

}

TY - JOUR

T1 - High expression of gli1 is associated with better survival in advanced sclc

AU - Kozirovskis, V.

AU - Zandberga, E.

AU - Magone, M.

AU - Purkalne, G.

AU - Line, A.

AU - Vikmanis, U.

N1 - Funding Information: This work was supported by the Latvian National Research Programme BIOMEDICINE 2014–2017. Publisher Copyright: © 2020 Morion LLC. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/3

Y1 - 2020/3

N2 - AIM: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival.MATERIALS AND METHODS: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor's samples (stratified by median survival, independent samples t-test).RESULTS: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor's biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test).CONCLUSION: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study.

AB - AIM: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data correlated with patient survival.MATERIALS AND METHODS: GLI1 expression was analyzed by quantitative real-time polymerase chain reaction in pre-treatment fresh frozen tumor biopsies of 12 advanced SCLC patients and mRNA level of GLI1 was compared in short-term vs long-term survivor's samples (stratified by median survival, independent samples t-test).RESULTS: Expression of GLI1 mRNA was significantly higher in long-term (> 9.6 months, n = 6) survivor's biopsies than in short-term (≤ 9.6 months, n = 6) survivors (p = 0.0196, 95% CI: 0.000016 to 0.000147, two-tailed independent samples t-test).CONCLUSION: High GLI1 mRNA expression in SCLC was found to be positive prognostic marker associated with longer survival. Further research is needed for validation of these results due to the small number of patients in the study.

KW - GLI1

KW - prognosis

KW - small cell lung cancer

KW - Sonic hedgehog pathway

KW - survival

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U2 - 10.32471/exp-oncology.2312-8852.vol-42-no-1.14266

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ER -

High expression of gli1 is associated with better survival in advanced sclc

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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