High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background: Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study. Material and methods: Study group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test. Results: MiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p=0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p=0.0314). Conclusions: Our finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients.

Original languageEnglish
Article number7
JournalHereditary cancer in clinical practice
Volume13
Issue number1
DOIs
Publication statusPublished - 8 Feb 2015

Keywords*

  • Hereditary and sporadic breast cancers
  • MiRNA expressionm
  • Triple-negative subtype

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients'. Together they form a unique fingerprint.

Cite this