TY - JOUR
T1 - High-Grade renal cell carcinoma with emperipolesis
T2 - Clinicopathological, immunohistochemical and Molecular-Genetic analysis of 14 cases
AU - Rotterova, Pavla
AU - Martinek, Petr
AU - Alaghehbandan, Reza
AU - Prochazkova, Kristyna
AU - Damjanov, Ivan
AU - Rogala, Joanna
AU - Suster, Saul
AU - Perez-Montiel, Delia
AU - Alvarado-Cabrero, Isabel
AU - Sperga, Maris
AU - Svajdler, Marian
AU - Michalova, Kvetoslava
AU - Pivovarcikova, Kristyna
AU - Daum, Ondrej
AU - Hora, Milan
AU - Dusek, Martin
AU - Ondic, Ondrej
AU - Stehlikova, Adela
AU - Michal, Michal
AU - Hes, Ondrej
N1 - Funding Information:
local ethical committee (Charles University, Medical School Plzen) LEK FN Plzeň. Funding: The study was supported by the Charles University Research Fund (project number P36) and by the project FN 00669806. Disclosure of Conflict of Interest: All authors declare no conflict of interest
Publisher Copyright:
© 2018, Histology and Histopathology. All Rights Reserved.
PY - 2018/3
Y1 - 2018/3
N2 - Emperipolesis has recently been described as a constant feature of “biphasic squamoid” papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC showing emperipolesis were retrieved from our registry. Microscopic examination of filed slides was supplemented with immunohistochemical and molecular-genetic analyses using paraffin embedded tissue. 12 of 14 patients were males with a mean age of 58.6 years (range 41-72 years). Tumor size ranged from 6-16.5 cm (mean of 8.8 cm). Follow up data were available for 8/14 patients (range 0.5-10 years). Metastases were documented in 6 cases. All tumors showed solid-alveolar growth patterns with focal pseudopapillary features, and were composed of large cells with bizarre nuclei and eosinophilic rhabdoid-like cytoplasm. Emperipolesis was a constant and prominent feature in large bizarre cells. All cases were positive for OSCAR, CANH 9, vimentin, cyclin D1, INI-1, and myoD1, while negative for melanocytic markers, CK 7, myoglobin, cathepsin K, and TFE3. VHL gene abnormalities were found in 6/9 analyzable cases, of which 2 demonstrated polysomy of chromosomes 7, 17. Emperipolesis is a rare histomorphologic feature which can be seen not only in BPRCCs but also in highgrade CCRCCs. All RCC cases with prominent emperipolesis fulfilled both morphologic and immunohistochemical diagnostic criteria of high-grade CCRCC. The majority of patients with available follow up information developed metastases.
AB - Emperipolesis has recently been described as a constant feature of “biphasic squamoid” papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC showing emperipolesis were retrieved from our registry. Microscopic examination of filed slides was supplemented with immunohistochemical and molecular-genetic analyses using paraffin embedded tissue. 12 of 14 patients were males with a mean age of 58.6 years (range 41-72 years). Tumor size ranged from 6-16.5 cm (mean of 8.8 cm). Follow up data were available for 8/14 patients (range 0.5-10 years). Metastases were documented in 6 cases. All tumors showed solid-alveolar growth patterns with focal pseudopapillary features, and were composed of large cells with bizarre nuclei and eosinophilic rhabdoid-like cytoplasm. Emperipolesis was a constant and prominent feature in large bizarre cells. All cases were positive for OSCAR, CANH 9, vimentin, cyclin D1, INI-1, and myoD1, while negative for melanocytic markers, CK 7, myoglobin, cathepsin K, and TFE3. VHL gene abnormalities were found in 6/9 analyzable cases, of which 2 demonstrated polysomy of chromosomes 7, 17. Emperipolesis is a rare histomorphologic feature which can be seen not only in BPRCCs but also in highgrade CCRCCs. All RCC cases with prominent emperipolesis fulfilled both morphologic and immunohistochemical diagnostic criteria of high-grade CCRCC. The majority of patients with available follow up information developed metastases.
KW - Clear cell renal cell carcinoma
KW - Emperipolesis
KW - High-grade
KW - Kidney
UR - http://www.scopus.com/inward/record.url?scp=85037030783&partnerID=8YFLogxK
U2 - 10.14670/HH-11-925
DO - 10.14670/HH-11-925
M3 - Article
C2 - 28861890
AN - SCOPUS:85037030783
SN - 0213-3911
VL - 33
SP - 277
EP - 287
JO - Histology and Histopathology
JF - Histology and Histopathology
IS - 3
ER -