Abstract
Objective: To compare the histological diagnosis of lung carcinoma in
biopsy and operation material in order to detect the frequency of morphological conformity.
Method: The retrospective study included 59 consecutive patients who
underwent both pulmonary biopsy and resection due to primary lung
carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon
necessity. Lung tumour classification by World Health Organization,
2015 was applied. Descriptive statistics was performed including detection of 95 % confidence interval (CI).
Results: The study group comprised 59 cases of which 44 (74.6 %;
CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy
and operation material by HE. These cases comprised squamous carcinomas (55.9 %; CI = 43.3–67.9), adenocarcinomas (11.9 %;
CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 %;
CI = 0.9–11.5). Fifteen tumours (25.4 %; CI = 16.1–37.8) were diagnosed
as non-small cell carcinomas by HE in the biopsy. Among these, 11
cancers (18.6 %; CI = 10.7–30.4) were attributed to specific histological
subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 %; CI = 2.7–16.2) remained as large cell carcinomas.
Conclusion: Three fourths of primary lung carcinoma can be reliably
diagnosed by HE in biopsy. The remaining cases necessitate investigation
of operation material (if available) and immunohistochemistry.
biopsy and operation material in order to detect the frequency of morphological conformity.
Method: The retrospective study included 59 consecutive patients who
underwent both pulmonary biopsy and resection due to primary lung
carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon
necessity. Lung tumour classification by World Health Organization,
2015 was applied. Descriptive statistics was performed including detection of 95 % confidence interval (CI).
Results: The study group comprised 59 cases of which 44 (74.6 %;
CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy
and operation material by HE. These cases comprised squamous carcinomas (55.9 %; CI = 43.3–67.9), adenocarcinomas (11.9 %;
CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 %;
CI = 0.9–11.5). Fifteen tumours (25.4 %; CI = 16.1–37.8) were diagnosed
as non-small cell carcinomas by HE in the biopsy. Among these, 11
cancers (18.6 %; CI = 10.7–30.4) were attributed to specific histological
subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 %; CI = 2.7–16.2) remained as large cell carcinomas.
Conclusion: Three fourths of primary lung carcinoma can be reliably
diagnosed by HE in biopsy. The remaining cases necessitate investigation
of operation material (if available) and immunohistochemistry.
| Original language | English |
|---|---|
| Article number | PS-13-013 |
| Pages (from-to) | S129-S129 |
| Number of pages | 1 |
| Journal | Virchows Archiv |
| Volume | 469 |
| Issue number | Suppl. 1 |
| Publication status | Published - Sept 2016 |
| Event | 31st International Congress of the International Academy of Pathology and the 28th Congress of the European Society of Pathology: Predictive pathology, guiding and monitoring therapy - Colgone, Germany Duration: 25 Sept 2016 → 29 Sept 2016 Conference number: 31 https://www.allcongress.com/medical-congress/31st-international-congress-of-the-international-academy-of-pathology-28th-congress-of-the-european-society-of-pathology/ |
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
Publication Type*
- 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database
