Histological conformity of primary lung carcinoma type in biopsy and operation material

Research output: Contribution to journalMeeting Abstractpeer-review


Objective: To compare the histological diagnosis of lung carcinoma in
biopsy and operation material in order to detect the frequency of morphological conformity.
Method: The retrospective study included 59 consecutive patients who
underwent both pulmonary biopsy and resection due to primary lung
carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon
necessity. Lung tumour classification by World Health Organization,
2015 was applied. Descriptive statistics was performed including detection of 95 % confidence interval (CI).
Results: The study group comprised 59 cases of which 44 (74.6 %;
CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy
and operation material by HE. These cases comprised squamous carcinomas (55.9 %; CI = 43.3–67.9), adenocarcinomas (11.9 %;
CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 %;
CI = 0.9–11.5). Fifteen tumours (25.4 %; CI = 16.1–37.8) were diagnosed
as non-small cell carcinomas by HE in the biopsy. Among these, 11
cancers (18.6 %; CI = 10.7–30.4) were attributed to specific histological
subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 %; CI = 2.7–16.2) remained as large cell carcinomas.
Conclusion: Three fourths of primary lung carcinoma can be reliably
diagnosed by HE in biopsy. The remaining cases necessitate investigation
of operation material (if available) and immunohistochemistry.
Original languageEnglish
Article numberPS-13-013
Pages (from-to)S129-S129
Number of pages1
JournalVirchows Archiv
Issue numberSuppl. 1
Publication statusPublished - Sept 2016
Event31st International Congress of the International Academy of Pathology and the 28th Congress of the European Society of Pathology: Predictive pathology, guiding and monitoring therapy - Colgone, Germany
Duration: 25 Sept 201629 Sept 2016
Conference number: 31

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database


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