Histological conformity of primary lung carcinoma type in biopsy and operation material

A. Jukna; I. Strumfa; A. Vanags; J. Gardovskis

Abstract

Objective: To compare the histological diagnosis of lung carcinoma in
biopsy and operation material in order to detect the frequency of morphological conformity.
Method: The retrospective study included 59 consecutive patients who
underwent both pulmonary biopsy and resection due to primary lung
carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon
necessity. Lung tumour classification by World Health Organization,
2015 was applied. Descriptive statistics was performed including detection of 95 % confidence interval (CI).
Results: The study group comprised 59 cases of which 44 (74.6 %;
CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy
and operation material by HE. These cases comprised squamous carcinomas (55.9 %; CI = 43.3–67.9), adenocarcinomas (11.9 %;
CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 %;
CI = 0.9–11.5). Fifteen tumours (25.4 %; CI = 16.1–37.8) were diagnosed
as non-small cell carcinomas by HE in the biopsy. Among these, 11
cancers (18.6 %; CI = 10.7–30.4) were attributed to specific histological
subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 %; CI = 2.7–16.2) remained as large cell carcinomas.
Conclusion: Three fourths of primary lung carcinoma can be reliably
diagnosed by HE in biopsy. The remaining cases necessitate investigation
of operation material (if available) and immunohistochemistry.

Original language	English
Article number	PS-13-013
Pages (from-to)	S129-S129
Number of pages	1
Journal	Virchows Archiv
Volume	469
Issue number	Suppl. 1
Publication status	Published - Sept 2016
Event	31st International Congress of the International Academy of Pathology and the 28th Congress of the European Society of Pathology: Predictive pathology, guiding and monitoring therapy - Colgone, Germany Duration: 25 Sept 2016 → 29 Sept 2016 Conference number: 31 https://www.allcongress.com/medical-congress/31st-international-congress-of-the-international-academy-of-pathology-28th-congress-of-the-european-society-of-pathology/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

Access to Document

https://link.springer.com/content/pdf/10.1007%2Fs00428-016-1997-7.pdf

Cite this

@article{c632ad5b543547638728e8c9792caa8d,

title = "Histological conformity of primary lung carcinoma type in biopsy and operation material",

abstract = "Objective: To compare the histological diagnosis of lung carcinoma in biopsy and operation material in order to detect the frequency of morphological conformity. Method: The retrospective study included 59 consecutive patients who underwent both pulmonary biopsy and resection due to primary lung carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon necessity. Lung tumour classification by World Health Organization, 2015 was applied. Descriptive statistics was performed including detection of 95 \% confidence interval (CI). Results: The study group comprised 59 cases of which 44 (74.6 \%; CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy and operation material by HE. These cases comprised squamous carcinomas (55.9 \%; CI = 43.3–67.9), adenocarcinomas (11.9 \%; CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 \%; CI = 0.9–11.5). Fifteen tumours (25.4 \%; CI = 16.1–37.8) were diagnosed as non-small cell carcinomas by HE in the biopsy. Among these, 11 cancers (18.6 \%; CI = 10.7–30.4) were attributed to specific histological subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 \%; CI = 2.7–16.2) remained as large cell carcinomas. Conclusion: Three fourths of primary lung carcinoma can be reliably diagnosed by HE in biopsy. The remaining cases necessitate investigation of operation material (if available) and immunohistochemistry.",

author = "A. Jukna and I. Strumfa and A. Vanags and J. Gardovskis",

year = "2016",

month = sep,

language = "English",

volume = "469",

pages = "S129--S129",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "Suppl. 1",

note = "31st International Congress of the International Academy of Pathology and the 28th Congress of the European Society of Pathology : Predictive pathology, guiding and monitoring therapy, IAP and ESP ; Conference date: 25-09-2016 Through 29-09-2016",

url = "https://www.allcongress.com/medical-congress/31st-international-congress-of-the-international-academy-of-pathology-28th-congress-of-the-european-society-of-pathology/",

}

TY - JOUR

T1 - Histological conformity of primary lung carcinoma type in biopsy and operation material

AU - Jukna, A.

AU - Strumfa, I.

AU - Vanags, A.

AU - Gardovskis, J.

N1 - Conference code: 31

PY - 2016/9

Y1 - 2016/9

N2 - Objective: To compare the histological diagnosis of lung carcinoma in biopsy and operation material in order to detect the frequency of morphological conformity. Method: The retrospective study included 59 consecutive patients who underwent both pulmonary biopsy and resection due to primary lung carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon necessity. Lung tumour classification by World Health Organization, 2015 was applied. Descriptive statistics was performed including detection of 95 % confidence interval (CI). Results: The study group comprised 59 cases of which 44 (74.6 %; CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy and operation material by HE. These cases comprised squamous carcinomas (55.9 %; CI = 43.3–67.9), adenocarcinomas (11.9 %; CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 %; CI = 0.9–11.5). Fifteen tumours (25.4 %; CI = 16.1–37.8) were diagnosed as non-small cell carcinomas by HE in the biopsy. Among these, 11 cancers (18.6 %; CI = 10.7–30.4) were attributed to specific histological subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 %; CI = 2.7–16.2) remained as large cell carcinomas. Conclusion: Three fourths of primary lung carcinoma can be reliably diagnosed by HE in biopsy. The remaining cases necessitate investigation of operation material (if available) and immunohistochemistry.

AB - Objective: To compare the histological diagnosis of lung carcinoma in biopsy and operation material in order to detect the frequency of morphological conformity. Method: The retrospective study included 59 consecutive patients who underwent both pulmonary biopsy and resection due to primary lung carcinoma. The histological tumour type was assessed in haematoxylineosin (HE) stained slides. Immunohistochemistry was performed upon necessity. Lung tumour classification by World Health Organization, 2015 was applied. Descriptive statistics was performed including detection of 95 % confidence interval (CI). Results: The study group comprised 59 cases of which 44 (74.6 %; CI = 62.2–83.9) showed morphological conformity of diagnosis in biopsy and operation material by HE. These cases comprised squamous carcinomas (55.9 %; CI = 43.3–67.9), adenocarcinomas (11.9 %; CI = 5.9–22.5), small cell carcinomas and carcinoids (each, 3.4 %; CI = 0.9–11.5). Fifteen tumours (25.4 %; CI = 16.1–37.8) were diagnosed as non-small cell carcinomas by HE in the biopsy. Among these, 11 cancers (18.6 %; CI = 10.7–30.4) were attributed to specific histological subtypes after evaluation of surgical material or by immunohistochemistry but 4 cases (6.8 %; CI = 2.7–16.2) remained as large cell carcinomas. Conclusion: Three fourths of primary lung carcinoma can be reliably diagnosed by HE in biopsy. The remaining cases necessitate investigation of operation material (if available) and immunohistochemistry.

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000388614501126

M3 - Meeting Abstract

SN - 0945-6317

VL - 469

SP - S129-S129

JO - Virchows Archiv

JF - Virchows Archiv

IS - Suppl. 1

M1 - PS-13-013

T2 - 31st International Congress of the International Academy of Pathology and the 28th Congress of the European Society of Pathology

Y2 - 25 September 2016 through 29 September 2016

ER -