Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus

A. Valdovska, M. Pilmane

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Parvovirus of Aleutian disease causes mainly damage to kidneys, but immune complexes deposition and damage may occur also in other organs. In mink farms of Latvia the liver dystrophy or hepatic lipidosis of mink is widely distributed. The goal of this study was to examine probability of liver damage and regeneration of mink infected with Aleutian disease virus. Liver injury was assessed histologically. The mink liver demonstrated inflammation of liver parenchyma and foci of fatty liver. In immunohistochemistry, during liver regeneration the matrix metalloproteinases MMP-9, vascular endothelial growth factor and ß-defensin 2 expressions were lower, but MMP-2 and nerve growth factor receptor p75 expression was increased.

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalPolish Journal of Veterinary Sciences
Volume14
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Aleutian disease
  • Immunohistochemistry
  • Liver
  • Mink

Field of Science

  • 3.1 Basic medicine
  • 4.3 Veterinary science

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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