HLA class II genes in Latvian patients with juvenile rheumatoid arthritis

I. Rumba, A. Denisova, A. Sochnev, B. Nilsson, C. B. Sanjeevi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

PCR-based HLA genotyping was used to analyze the association of HLA-DR and -DQ genes in 127 juvenile rheumatoid arthritis patients and 111 population-based controls froth Latvia. The results show DQA1*03 to be positively associated in overall patients and DRB 1*01-DQA1*0101-DQB1*0501 to be negatively associated with JRA in overall patients and in polyarthritis patients compared to controls. These data indicate the immunogenetic heterogeneity in the JRA patients, in the disease subgroups and in different ethnic groups. Rheumatoid factor (RF) was assayed in patients (n = 119) and controls (n = 98). RF was present in patients (7/119, 6%) compared to controls (5/98, 5%). None of the DQA1, DQB1 alleles, DQ and DR-DQ haplotypes was associated in seropositive patients compared to seropositive controls. DR1-DQ5 (DQA1*0101-B*0501) was decreased in seronegative patients (11/111, 10%) compared to seronegative controls (24/105, 23%), but the difference was not significant after correction of the p value.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalTissue Antigens
Volume49
Issue number1
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Genetic susceptibility
  • HLA-DQ
  • HLA-DR
  • JRA
  • Latvians
  • Rheumatoid factor

Field of Science

  • 1.6 Biological sciences
  • 1.4 Chemical sciences
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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