Abstract
The rare HLA-DQB1(*)0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P = 0.0001). HLA-DQB1(*)0304 in these populations was associated with DRB1(*)0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.
Original language | English |
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Pages (from-to) | 532-534 |
Number of pages | 3 |
Journal | Tissue Antigens |
Volume | 49 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1997 |
Externally published | Yes |
Keywords*
- HLA-DQB1(*)0304
- HLA-DR4 haplotype
- Insulin-dependent diabetes mellitus
Field of Science*
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database