HLA-DQB1(*)0304-DRB1(*)0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J. Ilonen, S. Koskinen, S. Nejentsev, M. Sjöroos, M. Knip, E. I. Schwartz, B. Adojaan, L. Kovalchuk, A. Sochnevs

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The rare HLA-DQB1(*)0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P = 0.0001). HLA-DQB1(*)0304 in these populations was associated with DRB1(*)0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

Original languageEnglish
Pages (from-to)532-534
Number of pages3
JournalTissue Antigens
Volume49
Issue number5
DOIs
Publication statusPublished - 1997
Externally publishedYes

Keywords*

  • HLA-DQB1(*)0304
  • HLA-DR4 haplotype
  • Insulin-dependent diabetes mellitus

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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