HLA-DQB1(*)0304-DRB1(*)0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J. Ilonen; S. Koskinen; S. Nejentsev; M. Sjöroos; M. Knip; E. I. Schwartz; B. Adojaan; L. Kovalchuk; A. Sochnevs

doi:10.1111/j.1399-0039.1997.tb02794.x

HLA-DQB1()0304-DRB1()0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

J. Ilonen
, S. Koskinen
, S. Nejentsev
, M. Sjöroos
, M. Knip
, E. I. Schwartz
, B. Adojaan
, L. Kovalchuk
, A. Sochnevs

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The rare HLA-DQB1(*)0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P = 0.0001). HLA-DQB1(*)0304 in these populations was associated with DRB1(*)0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

Original language	English
Pages (from-to)	532-534
Number of pages	3
Journal	Tissue Antigens
Volume	49
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-0039.1997.tb02794.x
Publication status	Published - 1997
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

HLA-DQB1(*)0304
HLA-DR4 haplotype
Insulin-dependent diabetes mellitus

Field of Science*

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1111/j.1399-0039.1997.tb02794.x

https://onlinelibrary-wiley-com.db.rsu.lv/doi/abs/10.1111/j.1399-0039.1997.tb02794.x

Cite this

@article{61135ca24a684980b13b8e0e680b7680,

title = "HLA-DQB1(*)0304-DRB1(*)0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region",

abstract = "The rare HLA-DQB1(*)0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5\% (20/443) compared to 1.1\% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P = 0.0001). HLA-DQB1(*)0304 in these populations was associated with DRB1(*)0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.",

keywords = "HLA-DQB1(*)0304, HLA-DR4 haplotype, Insulin-dependent diabetes mellitus",

author = "J. Ilonen and S. Koskinen and S. Nejentsev and M. Sj{\"o}roos and M. Knip and Schwartz, \{E. I.\} and B. Adojaan and L. Kovalchuk and A. Sochnevs",

year = "1997",

doi = "10.1111/j.1399-0039.1997.tb02794.x",

language = "English",

volume = "49",

pages = "532--534",

journal = "Tissue Antigens",

issn = "0001-2815",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "5",

}

TY - JOUR

T1 - HLA-DQB1(*)0304-DRB1(*)0408 haplotype associated with insulin-dependent diabetes mellitus in populations in the eastern Baltic region

AU - Ilonen, J.

AU - Koskinen, S.

AU - Nejentsev, S.

AU - Sjöroos, M.

AU - Knip, M.

AU - Schwartz, E. I.

AU - Adojaan, B.

AU - Kovalchuk, L.

AU - Sochnevs, A.

PY - 1997

Y1 - 1997

N2 - The rare HLA-DQB1(*)0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P = 0.0001). HLA-DQB1(*)0304 in these populations was associated with DRB1(*)0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

AB - The rare HLA-DQB1(*)0304 allele was found increased among IDDM patients in the populations of the eastern Baltic region. Its frequency among IDDM patients was 4.5% (20/443) compared to 1.1% (9/853) in healthy controls in the combined series of Estonian, Latvian and St. Petersburg Russian populations (P = 0.0001). HLA-DQB1(*)0304 in these populations was associated with DRB1(*)0408, and the haplotype was further characterized by a B35 allele and a typical combination of microsatellite markers from the TNF gene region. The result is compatible with the significance of the 57th amino acid in the DQ β-chain but also emphasizes the importance of alleles in other HLA loci adjacent to DQ in the determination of IDDM susceptibility.

KW - HLA-DQB1()0304

KW - HLA-DR4 haplotype

KW - Insulin-dependent diabetes mellitus

UR - https://www.scopus.com/pages/publications/0030612391

U2 - 10.1111/j.1399-0039.1997.tb02794.x

DO - 10.1111/j.1399-0039.1997.tb02794.x

M3 - Article

C2 - 9174152

AN - SCOPUS:0030612391

SN - 0001-2815

VL - 49

SP - 532

EP - 534

JO - Tissue Antigens

JF - Tissue Antigens

IS - 5

ER -