HLA II klases alēles juvenila idiopātiska artrīta slimniekiem ar temporomandibulāro locītavu artrītu

Translated title of the contribution: HLA II Class Alleles in Juvenile Idiopathic Arthritis Patients with Temporomandibular Joint Arthritis

Zane Dāvidsone, Jeļena Eglīte, Sarmite Dzelzite, Arina Lazareva, Ruta Šantere, Dace Berziņa, Valda Stanevica

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Temporomandibular joint (TMJ) arthritis is very often (38–87%) observed in children with juvenile
idiopathic arthritis. Contrast enhanced magnetic resonance imaging (MRI) is the golden standard for
the diagnosis of TMJ arthritis. Previous studies show that HLA II class alleles may have protective or risk
importance in JIA subtypes.
The aim of the study was to identify HLA II class alleles of risk and protection in JIA patients with
TMJ involvement.
53 JIA patients in who MRI for TMJ between 2010 and 2014 was performed were genotyped for
HLA-DRB1; DQB1; DQA1- using RT-PCR with sequence-specific primers. Associations of DRB1; DQB1;
DQA1 alleles in patients were examined individually using the χ2 test. P-value (< 0.05) and odds ratio were
calculated using EPI INFO 6.0 software.
53 JIA patients with mean age of 14.7 ± 1.2 years (range 1.2–17.9 years), 39 (73.6%) girls and
14 (26.4%) boys, were enrolled in the study. The mean duration of the disease was 3.9 ± 2.2 years
(range 0.2–10.2 years). JIA subtype was as follows: seronegative polyarthritis 29 (54.7%), seropositive
polyarthritis 6 (11.3%), oligoarthritis extended 4 (7.5%), arthritis with enthesitis 9 (17.0%), undifferentiated
2 (4.8%) and 2 (4.8%) for systemic arthritis. 2 groups were separated after TMJ MRI: 1st with signs of active
inflammation or any structural damage; 2nd with no pathologic signs or with slight contrast enhancement.
In the 1st group, alleles DRB1*16:01 (OR 0.90, p = 0.0001), *13:01 (OR 6.34, p = 0.001); DQB1*02:01–02:02
(OR 3.3, p = 0.001); DQA1*02:01 (OR 6.39, p = 0.041) where observed. In the 2nd group, DRB1*11:01 (OR
0.17, p = 0.0001); DQB1*03:01 (OR 0.3, p = 0.005), *05:01 (OR 0.4, p = 0.026); DQA1*05:01 (OR 0.22,
p = 0.001) were found more frequently.
JIA patients with alleles DRB1*16:01, *13:01; DQB1*02:01–02:02 and DQA1 *02:01 may have
higher risk for TMJ involvement. DRB1*11:01; DQB1 *03:01, *05:01 and DQA1 *05:01 alleles are probably
protective for TMJ involvement.
Translated title of the contributionHLA II Class Alleles in Juvenile Idiopathic Arthritis Patients with Temporomandibular Joint Arthritis
Original languageLatvian
Title of host publicationRīgas Stradiņa universitātes Zinātniskie raksti
Subtitle of host publication2014. gada medicīnas nozares pētnieciskā darba publikācijas
Place of PublicationRīga
PublisherRīgas Stradiņa universitāte
ISBN (Print)978-9984-793-68-9
Publication statusPublished - 2015


  • : temporomandibular joint arthritis
  • juvenile idiopathic arthritis
  • HLA II class alleles

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code


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