Human herpesvirus-6 and-7 in the brain microenvironment of persons with neurological pathology and healthy people

Research output: Contribution to journalArticlepeer-review

Abstract

During persistent human beta-herpesvirus (HHV) infection, clinical manifestations may not appear. However, the lifelong influence of HHV is often associated with pathological changes in the central nervous system. Herein, we evaluated possible associations between immunoex-pression of HHV-6,-7, and cellular immune response across different brain regions. The study aimed to explore HHV-6,-7 infection within the cortical lobes in cases of unspecified encephalo-pathy (UEP) and nonpathological conditions. We confirmed the presence of viral DNA by nPCR and viral antigens by immunohistochemistry. Overall, we have shown a significant increase (p < 0.001) of HHV antigen expression, especially HHV-7 in the temporal gray matter. Although HHV-infected neurons were found notably in the case of HHV-7, our observations suggest that higher (p < 0.001) cell tropism is associated with glial and endothelial cells in both UEP group and controls. HHV-6, predominantly detected in oligodendrocytes (p < 0.001), and HHV-7, predominantly detected in both astrocytes and oligodendrocytes (p < 0.001), exhibit varying effects on neural homeostasis. This indicates a high number (p < 0.001) of activated microglia observed in the temporal lobe in the UEP group. The question remains of whether human HHV contributes to neurological diseases or are markers for some aspect of the disease process.

Original languageEnglish
Article number2364
Pages (from-to)1-19
Number of pages19
JournalInternational Journal of Molecular Sciences
Volume22
Issue number5
DOIs
Publication statusPublished - 1 Mar 2021

Keywords

  • Frontal lobe
  • Human herpesvirus 6
  • Human herpesvirus 7
  • Immune re-sponse
  • Immunohistochemistry
  • PCR
  • Temporal lobe

Field of Science

  • 1.6 Biological sciences
  • 2.2 Electrical engineering, Electronic engineering, Information engineering

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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