Human herpesvirus-6 (HHV-6) involvement in thyroid autoimmunity - features of the study

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As HHV-6 can establish latency and reactivate, the infection can have long-lasting effects on its host and can contribute to the development autoimmune disorders, among them - autoimmune thyroiditis (AIT). The study of HHV-6 involvement in AIT development is difficult due to its viral properties. HHV-6 is ubiquitous and can be found in various tissues, and it can use cell-to-cell spread with immunomodulation to evade immune responses and thus lead to a persistent infection. Therefore, the study on HHV-6 involvement in autoimmune diseases requires the use of multiple disciplines - molecular biology, immunology and histology. In our studies we have used several polymerase chain reaction techniques, suspension multiplex immune assays and two types of immunohistochemistry. This multi-disciplinary approach has allowed us to gather interesting data on HHV-6 and AIT. We have found significantly higher frequency of HHV-6 and its active infection markers in patients' thyroid tissues. We have visually confirmed viral antigen presence in the diseased thyroid tissues and gathered immunological data that show an increased immune response to HHV-6 antigens in AIT patients.
Our results highlight the importance of a multi-disciplinary research approach and how it can provide a “bigger picture”, and can open up new directions of investigations.
Original languageEnglish
Publication statusPublished - 10 Jun 2022
Event8th National Conference with International Participation "Morphological Days" - The National Anthropological Museum, 73 Blvd. "Tsarigradsko shouse", Sofia, Sofia, Bulgaria
Duration: 10 Jun 202212 Jun 2022
Conference number: 8


Conference8th National Conference with International Participation "Morphological Days"
Internet address

Field of Science*

  • 3.3 Health sciences
  • 1.6 Biological sciences

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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