Human herpesvirus-6 (HHV-6) involvement in thyroid autoimmunity - features of the study

Maksims Čistjakovs; Lība Sokolovska; Alīna Sultanova; Modra Murovska

Abstract

As HHV-6 can establish latency and reactivate, the infection can have long-lasting effects on its host and can contribute to the development autoimmune disorders, among them - autoimmune thyroiditis (AIT). The study of HHV-6 involvement in AIT development is difficult due to its viral properties. HHV-6 is ubiquitous and can be found in various tissues, and it can use cell-to-cell spread with immunomodulation to evade immune responses and thus lead to a persistent infection. Therefore, the study on HHV-6 involvement in autoimmune diseases requires the use of multiple disciplines - molecular biology, immunology and histology. In our studies we have used several polymerase chain reaction techniques, suspension multiplex immune assays and two types of immunohistochemistry. This multi-disciplinary approach has allowed us to gather interesting data on HHV-6 and AIT. We have found significantly higher frequency of HHV-6 and its active infection markers in patients' thyroid tissues. We have visually confirmed viral antigen presence in the diseased thyroid tissues and gathered immunological data that show an increased immune response to HHV-6 antigens in AIT patients.
Our results highlight the importance of a multi-disciplinary research approach and how it can provide a “bigger picture”, and can open up new directions of investigations.

Original language	English
Pages	96-97
Publication status	Published - 10 Jun 2022
Event	8th National Conference with International Participation "Morphological Days" - The National Anthropological Museum, 73 Blvd. "Tsarigradsko shouse", Sofia, Sofia, Bulgaria Duration: 10 Jun 2022 → 12 Jun 2022 Conference number: 8 https://www.anatomy.bg/events/viii-national-conference-morphological-days http://ama-journal.com/morphological-days-2022/

Conference

Conference	8th National Conference with International Participation "Morphological Days"
Country/Territory	Bulgaria
City	Sofia
Period	10/06/22 → 12/06/22
Internet address	https://www.anatomy.bg/events/viii-national-conference-morphological-days http://ama-journal.com/morphological-days-2022/

Field of Science*

3.3 Health sciences
1.6 Biological sciences

Publication Type*

3.4. Other publications in conference proceedings (including local)

Cite this

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title = "Human herpesvirus-6 (HHV-6) involvement in thyroid autoimmunity - features of the study",

abstract = "As HHV-6 can establish latency and reactivate, the infection can have long-lasting effects on its host and can contribute to the development autoimmune disorders, among them - autoimmune thyroiditis (AIT). The study of HHV-6 involvement in AIT development is difficult due to its viral properties. HHV-6 is ubiquitous and can be found in various tissues, and it can use cell-to-cell spread with immunomodulation to evade immune responses and thus lead to a persistent infection. Therefore, the study on HHV-6 involvement in autoimmune diseases requires the use of multiple disciplines - molecular biology, immunology and histology. In our studies we have used several polymerase chain reaction techniques, suspension multiplex immune assays and two types of immunohistochemistry. This multi-disciplinary approach has allowed us to gather interesting data on HHV-6 and AIT. We have found significantly higher frequency of HHV-6 and its active infection markers in patients' thyroid tissues. We have visually confirmed viral antigen presence in the diseased thyroid tissues and gathered immunological data that show an increased immune response to HHV-6 antigens in AIT patients.Our results highlight the importance of a multi-disciplinary research approach and how it can provide a “bigger picture”, and can open up new directions of investigations.",

author = "Maksims {\v C}istjakovs and Lība Sokolovska and Alīna Sultanova and Modra Murovska",

year = "2022",

month = jun,

day = "10",

language = "English",

pages = "96--97",

note = "8th National Conference with International Participation {"}Morphological Days{"} ; Conference date: 10-06-2022 Through 12-06-2022",

url = "https://www.anatomy.bg/events/viii-national-conference-morphological-days, http://ama-journal.com/morphological-days-2022/",

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TY - CONF

T1 - Human herpesvirus-6 (HHV-6) involvement in thyroid autoimmunity - features of the study

AU - Čistjakovs, Maksims

AU - Sokolovska, Lība

AU - Sultanova, Alīna

AU - Murovska, Modra

N1 - Conference code: 8

PY - 2022/6/10

Y1 - 2022/6/10

N2 - As HHV-6 can establish latency and reactivate, the infection can have long-lasting effects on its host and can contribute to the development autoimmune disorders, among them - autoimmune thyroiditis (AIT). The study of HHV-6 involvement in AIT development is difficult due to its viral properties. HHV-6 is ubiquitous and can be found in various tissues, and it can use cell-to-cell spread with immunomodulation to evade immune responses and thus lead to a persistent infection. Therefore, the study on HHV-6 involvement in autoimmune diseases requires the use of multiple disciplines - molecular biology, immunology and histology. In our studies we have used several polymerase chain reaction techniques, suspension multiplex immune assays and two types of immunohistochemistry. This multi-disciplinary approach has allowed us to gather interesting data on HHV-6 and AIT. We have found significantly higher frequency of HHV-6 and its active infection markers in patients' thyroid tissues. We have visually confirmed viral antigen presence in the diseased thyroid tissues and gathered immunological data that show an increased immune response to HHV-6 antigens in AIT patients.Our results highlight the importance of a multi-disciplinary research approach and how it can provide a “bigger picture”, and can open up new directions of investigations.

AB - As HHV-6 can establish latency and reactivate, the infection can have long-lasting effects on its host and can contribute to the development autoimmune disorders, among them - autoimmune thyroiditis (AIT). The study of HHV-6 involvement in AIT development is difficult due to its viral properties. HHV-6 is ubiquitous and can be found in various tissues, and it can use cell-to-cell spread with immunomodulation to evade immune responses and thus lead to a persistent infection. Therefore, the study on HHV-6 involvement in autoimmune diseases requires the use of multiple disciplines - molecular biology, immunology and histology. In our studies we have used several polymerase chain reaction techniques, suspension multiplex immune assays and two types of immunohistochemistry. This multi-disciplinary approach has allowed us to gather interesting data on HHV-6 and AIT. We have found significantly higher frequency of HHV-6 and its active infection markers in patients' thyroid tissues. We have visually confirmed viral antigen presence in the diseased thyroid tissues and gathered immunological data that show an increased immune response to HHV-6 antigens in AIT patients.Our results highlight the importance of a multi-disciplinary research approach and how it can provide a “bigger picture”, and can open up new directions of investigations.

M3 - Abstract

SP - 96

EP - 97

T2 - 8th National Conference with International Participation "Morphological Days"

Y2 - 10 June 2022 through 12 June 2022