TY - JOUR
T1 - Human leukocyte antigens class II alleles affecting the response to 5-7 year antiretroviral therapy in A Latvian cohort
AU - Jasinskis, Vladislavs
AU - Koļesova, Oksana
AU - Koļesovs, Aleksandrs
AU - Rozentale, Baiba
AU - Ažiņa, Inga
AU - Kramiča, Ksenija
AU - Viksna, Ludmila
AU - Eglite, Jeļena
N1 - Publisher Copyright:
© 2019 Vladislavs Jasinskis et al., published by Sciendo 2019.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Antiretroviral therapy (ART) aims at suppressing viral replication and strengthening immune system in patients with HIV-1. Human Leukocyte Antigens (HLA) are among factors responsible for effectiveness of ART. The aim of this study was to determine the effect of HLA Class II alleles on the response to long-time ART, assessed by a change in CD4 + T-cell count in relation to viral load. The sample included 69 patients (17 females and 52 males) aged 20 to 50 with HIV-1 infection, who were undergoing ART in the Latvian Centre of Infectious Diseases. The median period of observation was 5.7 years. CD4 + T-cell count and viral load were analysed at the baseline and end of the period of observation. HLA typing was performed by polymerase chain reaction with low resolution sequence specific primers. Multiple hierarchical linear regression analysis confirmed that an increase in HIV-1 viral load was associated with a decrease in the level of CD4 + T-cell count. In addition, HLA-DRB1∗04 and HLA-DQB1∗06:01 alleles contributed negatively to the level of CD4 + T-cell count.
AB - Antiretroviral therapy (ART) aims at suppressing viral replication and strengthening immune system in patients with HIV-1. Human Leukocyte Antigens (HLA) are among factors responsible for effectiveness of ART. The aim of this study was to determine the effect of HLA Class II alleles on the response to long-time ART, assessed by a change in CD4 + T-cell count in relation to viral load. The sample included 69 patients (17 females and 52 males) aged 20 to 50 with HIV-1 infection, who were undergoing ART in the Latvian Centre of Infectious Diseases. The median period of observation was 5.7 years. CD4 + T-cell count and viral load were analysed at the baseline and end of the period of observation. HLA typing was performed by polymerase chain reaction with low resolution sequence specific primers. Multiple hierarchical linear regression analysis confirmed that an increase in HIV-1 viral load was associated with a decrease in the level of CD4 + T-cell count. In addition, HLA-DRB1∗04 and HLA-DQB1∗06:01 alleles contributed negatively to the level of CD4 + T-cell count.
KW - ART
KW - CD4 T cells
KW - HIV-1
KW - HLA Class II
UR - http://www.scopus.com/inward/record.url?scp=85065646256&partnerID=8YFLogxK
U2 - 10.2478/prolas-2019-0014
DO - 10.2478/prolas-2019-0014
M3 - Article
AN - SCOPUS:85065646256
SN - 1407-009X
VL - 73
SP - 84
EP - 88
JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
IS - 2
ER -
