Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections

Ushanandini Mohanraj, Maija Jokinen, Rajita Rayamajhi Thapa, Minna Paloniemi, Timo Vesikari, Maija Lappalainen, Eveliina Tarkka, Zaiga Nora-Krūkle, Anda Vilmane, Kim Vettenranta, Charles Mangani, Sami Oikarinen, Yue Mei Fan, Per Ashorn, Elina Väisänen, Maria Söderlund-Venermo

Research output: Contribution to journalArticlepeer-review

Abstract

Three human protoparvoviruses, bufavirus (BuV), tusavirus (TuV) and cutavirus (CuV), have recently been discovered in diarrheal stool. BuV has been associated with diarrhea and CuV with cutaneous T-cell lymphoma, but there are hardly any data for TuV or CuV in stool or respiratory samples. Hence, using qPCR and IgG enzyme immunoassays, we analyzed 1072 stool, 316 respiratory and 445 serum or plasma samples from 1098 patients with and without gastroenteritis (GE) or respiratory-tract infections (RTI) from Finland, Latvia and Malawi. The overall CuV-DNA prevalences in stool samples ranged between 0-6.1% among our six patient cohorts. In Finland, CuV DNA was significantly more prevalent in GE patients above rather than below 60 years of age (5.1% vs 0.2%). CuV DNA was more prevalent in stools among Latvian and Malawian children compared with Finnish children. In 10/11 CuV DNA-positive adults and 4/6 CuV DNA-positive children with GE, no known causal pathogens were detected. Interestingly, for the first time, CuV DNA was observed in two nasopharyngeal aspirates from children with RTI and the rare TuV in diarrheal stools of two adults. Our results provide new insights on the occurrence of human protoparvoviruses in GE and RTI in different countries.

Original languageEnglish
Article number483
Number of pages14
JournalViruses
Volume13
Issue number3
DOIs
Publication statusPublished - 15 Mar 2021

Keywords

  • bufavirus
  • cutavirus
  • gastroenteritis
  • leukemia
  • parvovirus
  • PCR
  • respiratory-tract infection
  • serology
  • tusavirus

Field of Science

  • 1.6 Biological sciences
  • 3.3 Health sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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