Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold

M. Teus, A. Jirgensons, M. Dambrova, R. Mezhapuke, C. G. Parsons, W. Danysz

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalLetters in Drug Design and Discovery
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Keywords*

  • 5-hydroxyisoxazole
  • Glutamate
  • Glutamate carboxypeptidase II
  • Lipophilicity
  • Synthesis

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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