Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold

M. Teus; A. Jirgensons; M. Dambrova; R. Mezhapuke; C. G. Parsons; W. Danysz

doi:10.2174/157018009787158544

Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold

M. Teus
, A. Jirgensons^*
, M. Dambrova
, R. Mezhapuke
, C. G. Parsons
, W. Danysz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	Letters in Drug Design and Discovery
Volume	6
Issue number	1
DOIs	https://doi.org/10.2174/157018009787158544
Publication status	Published - Jan 2009
Externally published	Yes

Keywords*

5-hydroxyisoxazole
Glutamate
Glutamate carboxypeptidase II
Lipophilicity
Synthesis

Field of Science

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

Access to Document

10.2174/157018009787158544

Cite this

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title = "Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold",

abstract = "Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.",

keywords = "5-hydroxyisoxazole, Glutamate, Glutamate carboxypeptidase II, Lipophilicity, Synthesis",

author = "M. Teus and A. Jirgensons and M. Dambrova and R. Mezhapuke and Parsons, \{C. G.\} and W. Danysz",

year = "2009",

month = jan,

doi = "10.2174/157018009787158544",

language = "English",

volume = "6",

pages = "29--32",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

publisher = "KeAi Publishing Communications Ltd.",

number = "1",

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TY - JOUR

T1 - Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold

AU - Teus, M.

AU - Jirgensons, A.

AU - Dambrova, M.

AU - Mezhapuke, R.

AU - Parsons, C. G.

AU - Danysz, W.

PY - 2009/1

Y1 - 2009/1

N2 - Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

AB - Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

KW - 5-hydroxyisoxazole

KW - Glutamate

KW - Glutamate carboxypeptidase II

KW - Lipophilicity

KW - Synthesis

UR - https://www.scopus.com/pages/publications/61849129674

U2 - 10.2174/157018009787158544

DO - 10.2174/157018009787158544

M3 - Article

AN - SCOPUS:61849129674

SN - 1570-1808

VL - 6

SP - 29

EP - 32

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 1

ER -

Identification of GCP II inhibitors based on 4-arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole scaffold

Abstract

Keywords*

Field of Science

Publication Type*

ASJC Scopus subject areas

Access to Document

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