Identifying the stage of new CLL patients using TK, ZAP-70, CD38 levels

A. Rivkina, G. Vitols, M. Murovska, S. Lejniece

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Serum thymidine kinase (TK), zeta-associated protein of 70 kDa (ZAP-70) and CD38 levels have been shown to be correlated with survival in chronic lymphocytic leukaemia (CLL). Aim: To investigate the possible correlations between TK, ZAP-70 and CD38 levels as prognostic markers in new diagnosed Rai stages of CLL patients. Methods: 120 CLL patients were enrolled. ELISA was used to measure serum TK level, flow cytomerty - to determine ZAP-70 and CD38 expression applying ZAP-70 Kit and monoclonal antibody to CD38, respectively. Results: Significantly higher levels of TK were found in the high progression group of CLL patients that corresponded to stage II (Rai classification). An elevated level of TK, CD38 and ZAP-70 together was also found in the II stage. The coefficient of correlation between CD38 and ZAP-70 is reliable (p < 0.001). There is also a correlation between the level of TK and the disease stage (p < 0.05). Other parameters do not show this correlation. Conclusion: The determination of TK, ZAP-70 and CD38 together allows patients susceptible to a possible stage of the disease, to be identified. Estimation of the factors at an early stage of the disease may allow an earlier commencement of treatment.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalExperimental Oncology
Volume33
Issue number2
Publication statusPublished - Jun 2011

Keywords

  • CD38
  • Chronic lymphocytic leukaemia
  • ELISA
  • Flow cytometry
  • TK
  • ZAP-70

Field of Science

  • 1.6 Biological sciences
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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