Iedzimto augšlūpas/aukslēju šķeltņu ģenētiskie aspekti Latvijā

Translated title of the contribution: Genetic aspects of cleft lip/palate in Latvia

G. Puriņa, Biruta Barkāne, Natālija Grasmane, Ļ. Sokolova, A. Mārtiņsons

Research output: Contribution to journalArticlepeer-review


During the years 1981-90, 552 cases of isolated cleft lip/palate were registered (mean incidence was 13.77 per 10.000 newborns). No statistical difference was found in the dynamics; however, since 1990, a significant increase in cleft lip/palate defects (17.21; p lt 0.05) was detected. Associated defects among living patients (42 cases) were recorded more frequently than in several European countries. Among 89 postmortem cases with multiple malformation including cleft lip/palate, there were 9 cases of gametopathies (7 chromosme, and 2 gene syndromes), 3 blastopathies, and 1 embryopathy. Analysis of cleft lip/palate prevalence among proband relatives (795 families) revealed that the frequency was 9-10 times higher than it was in the general population. Of 795 probands, 92.7% were sporadic cases.
Translated title of the contributionGenetic aspects of cleft lip/palate in Latvia
Original languageLatvian
Pages (from-to)49-52
JournalProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
Issue number8
Publication statusPublished - 1992
Externally publishedYes


  • cleft lip/palate
  • epidemiology
  • congenital malformations
  • genetics

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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