Abstract
During the years 1981-90, 552 cases of isolated cleft lip/palate were registered (mean incidence was 13.77 per 10.000 newborns). No statistical difference was found in the dynamics; however, since 1990, a significant increase in cleft lip/palate defects (17.21; p lt 0.05) was detected. Associated defects among living patients (42 cases) were recorded more frequently than in several European countries. Among 89 postmortem cases with multiple malformation including cleft lip/palate, there were 9 cases of gametopathies (7 chromosme, and 2 gene syndromes), 3 blastopathies, and 1 embryopathy. Analysis of cleft lip/palate prevalence among proband relatives (795 families) revealed that the frequency was 9-10 times higher than it was in the general population. Of 795 probands, 92.7% were sporadic cases.
| Translated title of the contribution | Genetic aspects of cleft lip/palate in Latvia |
|---|---|
| Original language | Latvian |
| Pages (from-to) | 49-52 |
| Journal | Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. |
| Issue number | 8 |
| Publication status | Published - 1992 |
| Externally published | Yes |
Keywords*
- cleft lip/palate
- epidemiology
- congenital malformations
- genetics
Field of Science*
- 3.2 Clinical medicine
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database