Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

Alexey Lihachev (Coresponding Author), Emilija Vija Plorina, Marta Lange, Ilze Lihacova, Alexander Derjabo, Dmitrijs Bliznuks

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2019
PublisherOSA - The Optical Society
ISBN (Electronic)9781557528209
Publication statusPublished - 2019
Externally publishedYes
EventEuropean Conference on Biomedical Optics (ECBO) - Munich, Germany
Duration: 23 Jun 201925 Jun 2019,p185467203

Publication series

NameOptics InfoBase Conference Papers
VolumePart F142-ECBO 2019


ConferenceEuropean Conference on Biomedical Optics (ECBO)
Abbreviated titleECBO 2019
Internet address


  • Autofluorescence
  • Photobleaching
  • Skin diagnostics

Field of Science*

  • 1.3 Physical sciences
  • 2.6 Medical engineering

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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