Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

Alexey Lihachev; Emilija Vija Plorina; Marta Lange; Ilze Lihacova; Alexander Derjabo; Dmitrijs Bliznuks

doi:10.1117/12.2526260

Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

Alexey Lihachev^*
, Emilija Vija Plorina
, Marta Lange
, Ilze Lihacova
, Alexander Derjabo
, Dmitrijs Bliznuks

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

1 Citation (Scopus)

Abstract

The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.

Original language	English
Title of host publication	European Conference on Biomedical Optics, ECBO 2019
Publisher	OSA - The Optical Society
ISBN (Electronic)	9781557528209
DOIs	https://doi.org/10.1117/12.2526260
Publication status	Published - 2019
Externally published	Yes
Event	European Conference on Biomedical Optics (ECBO) - Munich, Germany Duration: 23 Jun 2019 → 25 Jun 2019 https://opg.optica.org/conference.cfm?meetingid=62&yr=2019 http://www.create.edu.pl/events/conferences-seminars/ecbo-2019---european-conferences-on-biomedical-optics,p185467203 https://www.proceedings.com/spie11073.html

Publication series

Name	Optics InfoBase Conference Papers
Volume	Part F142-ECBO 2019

Conference

Conference	European Conference on Biomedical Optics (ECBO)
Abbreviated title	ECBO 2019
Country/Territory	Germany
City	Munich
Period	23/06/19 → 25/06/19
Internet address	https://opg.optica.org/conference.cfm?meetingid=62&yr=2019 http://www.create.edu.pl/events/conferences-seminars/ecbo-2019---european-conferences-on-biomedical-optics,p185467203 https://www.proceedings.com/spie11073.html

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

Autofluorescence
Photobleaching
Skin diagnostics

Field of Science

2.6 Medical engineering
1.3 Physical sciences

Publication Type*

3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

Access to Document

10.1117/12.2526260

Cite this

@inproceedings{8927c28fbc7e4934850f7df845680bd3,

title = "Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics",

abstract = "The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of \textasciitilde{}7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.",

keywords = "Autofluorescence, Photobleaching, Skin diagnostics",

author = "Alexey Lihachev and Plorina, \{Emilija Vija\} and Marta Lange and Ilze Lihacova and Alexander Derjabo and Dmitrijs Bliznuks",

note = "Funding Information: This work has been supported by two European Regional Development Fund projects {\textquotedblleft}Time-resolved autofluorescence methodology for non-invasive skin cancer diagnostics{\textquotedblright} (No. 1.1.1.2/16/I/001, agreement No. 1.1.1.2/VIAA/1/16/014) and {\textquotedblleft}Portable device for noncontact skin cancer early diagnostics{\textquotedblright} (No. 1.1.1.1/16/A/197). Publisher Copyright: {\textcopyright} SPIE-OSA 2019; European Conference on Biomedical Optics (ECBO), ECBO 2019 ; Conference date: 23-06-2019 Through 25-06-2019",

year = "2019",

doi = "10.1117/12.2526260",

language = "English",

series = "Optics InfoBase Conference Papers",

publisher = "OSA - The Optical Society",

booktitle = "European Conference on Biomedical Optics, ECBO 2019",

address = "United States",

url = "https://opg.optica.org/conference.cfm?meetingid=62\&yr=2019, http://www.create.edu.pl/events/conferences-seminars/ecbo-2019---european-conferences-on-biomedical-optics,p185467203, https://www.proceedings.com/spie11073.html",

}

Lihachev, A, Plorina, EV, Lange, M, Lihacova, I, Derjabo, A & Bliznuks, D 2019, Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics. in European Conference on Biomedical Optics, ECBO 2019. Optics InfoBase Conference Papers, vol. Part F142-ECBO 2019, OSA - The Optical Society, European Conference on Biomedical Optics (ECBO), Munich, Germany, 23/06/19. https://doi.org/10.1117/12.2526260

Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics. / Lihachev, Alexey; Plorina, Emilija Vija; Lange, Marta et al.
European Conference on Biomedical Optics, ECBO 2019. OSA - The Optical Society, 2019. (Optics InfoBase Conference Papers; Vol. Part F142-ECBO 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

TY - GEN

T1 - Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

AU - Lihachev, Alexey

AU - Plorina, Emilija Vija

AU - Lange, Marta

AU - Lihacova, Ilze

AU - Derjabo, Alexander

AU - Bliznuks, Dmitrijs

N1 - Funding Information: This work has been supported by two European Regional Development Fund projects “Time-resolved autofluorescence methodology for non-invasive skin cancer diagnostics” (No. 1.1.1.2/16/I/001, agreement No. 1.1.1.2/VIAA/1/16/014) and “Portable device for noncontact skin cancer early diagnostics” (No. 1.1.1.1/16/A/197). Publisher Copyright: © SPIE-OSA 2019

PY - 2019

Y1 - 2019

N2 - The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.

AB - The aim of this study is to develop a novel non-invasive approach for skin cancer (melanoma, basal cell and squamous cell carcinomas) diagnostics by mapping the AF intensity decrease (photo-bleaching) rates under continuous 405 nm LED excitation. For parametric mapping of skin AF intensity decrease rates a sequence of filtered AF imaging under 405 nm LED excitation for 20 seconds at a power density of ~7 mW/cm2 with a frame rate 0.5 fps was recorded and analyzed by cloud-based prototype device. Several clinical cases and potential future applications of the proposed autofluorescence photobleaching rate imaging technique are discussed.

KW - Autofluorescence

KW - Photobleaching

KW - Skin diagnostics

UR - https://www.scopus.com/pages/publications/85084465219

U2 - 10.1117/12.2526260

DO - 10.1117/12.2526260

M3 - Conference contribution

AN - SCOPUS:85084465219

T3 - Optics InfoBase Conference Papers

BT - European Conference on Biomedical Optics, ECBO 2019

PB - OSA - The Optical Society

T2 - European Conference on Biomedical Optics (ECBO)

Y2 - 23 June 2019 through 25 June 2019

ER -

Imaging of LED-excited autofluorescence photobleaching rates for skin lesion diagnostics

Abstract

Publication series

Conference

UN SDGs

Keywords*

Field of Science

Publication Type*

ASJC Scopus subject areas

Access to Document

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Cite this