Immunogenetic Manifestations of Lyme Borreliosis

Lilija Kovačuka, Jeļena Eglīte, Māra Zālīte, Irina Lucenko, Ludmila Vīksna, Angelika Krūmiņa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume70
Issue number4
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • HLA alleles
  • Lyme borreliosis
  • PCR-SSP

Field of Science

  • 1.6 Biological sciences
  • 3.3 Health sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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