Immunogenetic Manifestations of Lyme Borreliosis

Lilija Kovačuka; Jeļena Eglīte; Māra Zālīte; Irina Lucenko; Ludmila Vīksna; Angelika Krūmiņa

doi:10.1515/prolas-2016-0034

Immunogenetic Manifestations of Lyme Borreliosis

Lilija Kovačuka
, Jeļena Eglīte
, Māra Zālīte
, Irina Lucenko
, Ludmila Vīksna
, Angelika Krūmiņa

Department of Infectology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

13 Downloads (Pure)

Abstract

In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.

Original language	English
Pages (from-to)	215-219
Number of pages	5
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	70
Issue number	4
DOIs	https://doi.org/10.1515/prolas-2016-0034
Publication status	Published - 1 Aug 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

HLA alleles
Lyme borreliosis
PCR-SSP

Field of Science*

1.6 Biological sciences
3.3 Health sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1515/prolas-2016-0034

Immunogenetic Manifestations of Lyme BorreliosisLicence: CC BY-NC-ND

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title = "Immunogenetic Manifestations of Lyme Borreliosis",

abstract = "In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.",

keywords = "HLA alleles, Lyme borreliosis, PCR-SSP",

author = "Lilija Kova{\v c}uka and Jeļena Eglīte and Māra Zālīte and Irina Lucenko and Ludmila Vīksna and Angelika Krūmiņa",

year = "2016",

month = aug,

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doi = "10.1515/prolas-2016-0034",

language = "English",

volume = "70",

pages = "215--219",

journal = "Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences",

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T1 - Immunogenetic Manifestations of Lyme Borreliosis

AU - Kovačuka, Lilija

AU - Eglīte, Jeļena

AU - Zālīte, Māra

AU - Lucenko, Irina

AU - Vīksna, Ludmila

AU - Krūmiņa, Angelika

PY - 2016/8/1

Y1 - 2016/8/1

N2 - In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.

AB - In this study, we sought to identify human leukocyte antigen (HLA) DRB1 alleles that might be associated with Lyme borreliosis in Latvian patients. Case patients and control subjects were similar in age, sex, and ethnic heritage and differed only in the presence of Borrelia burgdorferi infection. The frequency of HLA-DRB1∗07 (OR 3.52; p = 0.001), HLA-DRB1∗15 (OR 3.02; p = 0.001) and HLA-DRB1 ∗17 (03) (OR 2.63; p = 0.001) were significantly increased in the Lyme disease patients compared with the control groups. The frequency of the alleles-DRB1∗11(OR 0.37; p = 0.005) and-DRB1∗13 (OR 0.34; p = 0.002) was smaller in Borreliosis patients and significantly higher in the control group.

KW - HLA alleles

KW - Lyme borreliosis

KW - PCR-SSP

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DO - 10.1515/prolas-2016-0034

M3 - Article

AN - SCOPUS:84983417758

SN - 1407-009X

VL - 70

SP - 215

EP - 219

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 4

ER -

Immunogenetic Manifestations of Lyme Borreliosis

Abstract

UN SDGs

Keywords*

Field of Science*

Publication Type*

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