TY - JOUR
T1 - Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis
AU - Kovalchuka, Lilija
AU - Cvetkova, Svetlana
AU - Trofimova, Julija
AU - Eglite, Jelena
AU - Gintere, Sandra
AU - Lucenko, Irina
AU - Oczko-Grzesik, Barbara
AU - Viksna, Ludmila
AU - Krumina, Angelika
N1 - Funding Information:
This work was supported by the European Social Fund (ESF) project ?Support for doctoral study program and scientific degree receiving in Riga Stradi?? University, agreement No. 2009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009?.
Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.
AB - The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.
KW - Borrelia burgdorferi
KW - HLA-DRB1
KW - Immunogenetic markers
KW - Lyme borreliosis
KW - Lyme neuroborreliosis
UR - http://www.scopus.com/inward/record.url?scp=85003634558&partnerID=8YFLogxK
U2 - 10.3390/ijerph13121194
DO - 10.3390/ijerph13121194
M3 - Article
C2 - 27916969
AN - SCOPUS:85003634558
SN - 1661-7827
VL - 13
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 12
M1 - 1194
ER -
