Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis

Lilija Kovalchuka; Svetlana Cvetkova; Julija Trofimova; Jelena Eglite; Sandra Gintere; Irina Lucenko; Barbara Oczko-Grzesik; Ludmila Viksna; Angelika Krumina

doi:10.3390/ijerph13121194

Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis

Lilija Kovalchuka
, Svetlana Cvetkova
, Julija Trofimova
, Jelena Eglite
, Sandra Gintere
, Irina Lucenko
, Barbara Oczko-Grzesik
, Ludmila Viksna
, Angelika Krumina

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

7 Downloads (Pure)

Abstract

The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

Original language	English
Article number	1194
Journal	International Journal of Environmental Research and Public Health
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/ijerph13121194
Publication status	Published - 1 Dec 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

Borrelia burgdorferi
HLA-DRB1
Immunogenetic markers
Lyme borreliosis
Lyme neuroborreliosis

Field of Science*

3.3 Health sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3390/ijerph13121194

Immunogenetic Markers Definition in Latvian PatientsLicence: CC BY

Cite this

@article{3e48fb85abf24a568f03aa25b29baf91,

title = "Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis",

abstract = "The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.",

keywords = "Borrelia burgdorferi, HLA-DRB1, Immunogenetic markers, Lyme borreliosis, Lyme neuroborreliosis",

author = "Lilija Kovalchuka and Svetlana Cvetkova and Julija Trofimova and Jelena Eglite and Sandra Gintere and Irina Lucenko and Barbara Oczko-Grzesik and Ludmila Viksna and Angelika Krumina",

note = "Funding Information: This work was supported by the European Social Fund (ESF) project ?Support for doctoral study program and scientific degree receiving in Riga Stradi?? University, agreement No. 2009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009?. Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2016",

month = dec,

day = "1",

doi = "10.3390/ijerph13121194",

language = "English",

volume = "13",

journal = "International Journal of Environmental Research and Public Health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis

AU - Kovalchuka, Lilija

AU - Cvetkova, Svetlana

AU - Trofimova, Julija

AU - Eglite, Jelena

AU - Gintere, Sandra

AU - Lucenko, Irina

AU - Oczko-Grzesik, Barbara

AU - Viksna, Ludmila

AU - Krumina, Angelika

N1 - Funding Information: This work was supported by the European Social Fund (ESF) project ?Support for doctoral study program and scientific degree receiving in Riga Stradi?? University, agreement No. 2009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009?. Publisher Copyright: © 2016 by the authors; licensee MDPI, Basel, Switzerland. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

AB - The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

KW - Borrelia burgdorferi

KW - HLA-DRB1

KW - Immunogenetic markers

KW - Lyme borreliosis

KW - Lyme neuroborreliosis

UR - https://www.scopus.com/pages/publications/85003634558

U2 - 10.3390/ijerph13121194

DO - 10.3390/ijerph13121194

M3 - Article

C2 - 27916969

AN - SCOPUS:85003634558

SN - 1661-7827

VL - 13

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 12

M1 - 1194

ER -

Immunogenetic markers definition in latvian patients with lyme borreliosis and lyme neuroborreliosis

Abstract

UN SDGs

Keywords*

Field of Science*

Publication Type*

Access to Document

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