Augšstilba kaula lielā grozītāja kaulaudu kvantitatīva imūnhistoķīmiska analīze pacientiem ar osteoporotiskiem lūzumiem

Translated title of the contribution: Immunohistochemical Quantitative Analysis of Bone Tissue from Great Tochanter of Femur in Patients with Osteoporotic Fractures

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Introduction. Fractures of the proximal femur are the most common hospital treated fractures
with relatively higher mortality and disability. Following radiological techniques are commonly used for
bone evaluation: X-ray, computed tomography and osteodensitometry. Additional important information
on bone morphology and protein activity can be obtained by using immunohistochemical methods. Thus,
it is possible to reveal morphopathogenesis, determine bone quality and predict the outcome of surgical
treatment. The main bone activity indicators today are: growth factors, bone basic substance indicators
and bone activity indicators.
Material and methods. The analysis is based on bone tissue from great trochanter of femur
from eleven patients, females, mean age 80.6 years, who were treated in Rīga 2nd Hospital in 2012 with
pertrochanteric fractures after low energy trauma – fall.
Results. Bone cells of all patients moderately contained osteocalcin, while cells containing
osteopontin, proved to be variable. A small amount of osteoprotegerin containing cells was found;
however, in exceptional cases the mentioned factor contained up to an average amount of cells in
the visual field. Bone regeneration protein containing cells in the majority of cases were not found at
all, except for some samples. Transforming growth factor beta containing cells were found little or very
little in almost all samples. In all preparations, marked bone atrophy was evident.
Conclusions. Patients with pertrochanteric osteoporotic fractures has a small amount of
bone cells that contain cell activity and bone growth and recovery enhancing growth factors due to
osteoporosis, as well as aging. Most stable of basic proteins of bone tissue affected by osteoporosis
is osteocalcin, while osteopontin is almost missing determining severe bone deterioration. Low
expression of osteoprotegerin indicates a reduced osteoclast inhibition, which is an important factor in
the development of osteoporosis.
Translated title of the contributionImmunohistochemical Quantitative Analysis of Bone Tissue from Great Tochanter of Femur in Patients with Osteoporotic Fractures
Original languageLatvian
Title of host publicationRīgas Stradiņa universitātes Zinātniskie raksti
Subtitle of host publication2013. gada medicīnas nozares pētnieciskā darba publikācijas
Place of PublicationRīga
PublisherRīgas Stradiņa universitāte
Pages330-335
ISBN (Print)978-9984-793-56-6
Publication statusPublished - 2014

Publication series

NameRSU Zinātniskie Raksti
ISSN (Print)1407-9453

Keywords*

  • osteoporoze
  • augšstilba kaula proksimālās daļas lūzumi
  • histoķīmija
  • osteokalcīns (OC)
  • osteopontīns (OPN)
  • kaulu reģenerācijas proteīni 2 un 4 (BMP 2/4)
  • transformējošais augšanas faktors beta (TGF β)
  • osteoprotegerīns (OPG)

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code

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