Immunosuppressive Mechanisms of Regulatory B Cells

Diego Catalán, Miguel Andrés Mansilla, Ashley Ferrier, Lilian Soto, Kristine Oleinika, Juan Carlos Aguillón, Octavio Aravena

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing immune responses and reestablishing immune homeostasis. The important role of Bregs in restraining the pathology associated with exacerbated inflammatory responses in autoimmunity and graft rejection has been consistently demonstrated, while more recent studies have suggested a role for this population in other immune-related conditions, such as infections, allergy, cancer, and chronic metabolic diseases. Initial studies identified IL-10 as the hallmark of Breg function; nevertheless, the past decade has seen the discovery of other molecules utilized by human and murine B cells to regulate immune responses. This new arsenal includes other anti-inflammatory cytokines such IL-35 and TGF-β, as well as cell surface proteins like CD1d and PD-L1. In this review, we examine the main suppressive mechanisms employed by these novel Breg populations. We also discuss recent evidence that helps to unravel previously unknown aspects of the phenotype, development, activation, and function of IL-10-producing Bregs, incorporating an overview on those questions that remain obscure.

Original languageEnglish
Article number611795
Number of pages30
JournalFrontiers in Immunology
Volume12
DOIs
Publication statusPublished - 29 Apr 2021

Keywords*

  • CD1d
  • granzyme B
  • IL-10
  • IL-35
  • PD-L1
  • regulatory B cells
  • TGF-β
  • TIM-1

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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