Impact of KRAS variant rs61764370 on breast cancer morbidity

M. Ustinova; Z. Daneberga; D. Bērziņa; M. Nakazawa-Miklaševiča; J. Maksimenko; J. Gardovskis; E. Miklaševičs

doi:10.31768/2312-8852.2015.37(4):292-294

Impact of KRAS variant rs61764370 on breast cancer morbidity

M. Ustinova, Z. Daneberga, D. Bērziņa, M. Nakazawa-Miklaševiča, J. Maksimenko, J. Gardovskis, E. Miklaševičs

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3' UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates.

Original language	English
Pages (from-to)	292-294
Number of pages	3
Journal	Experimental Oncology
Volume	37
Issue number	4
DOIs	https://doi.org/10.31768/2312-8852.2015.37(4):292-294
Publication status	Published - Dec 2015

Keywords*

Breast cancer
KRAS variant
Predisposing factor
Rs61764370

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.31768/2312-8852.2015.37(4):292-294

Cite this

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title = "Impact of KRAS variant rs61764370 on breast cancer morbidity",

abstract = "Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3' UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates.",

keywords = "Breast cancer, KRAS variant, Predisposing factor, Rs61764370",

author = "M. Ustinova and Z. Daneberga and D. Bērziņa and M. Nakazawa-Mikla{\v s}evi{\v c}a and J. Maksimenko and J. Gardovskis and E. Mikla{\v s}evi{\v c}s",

note = "Publisher Copyright: Copyright {\textcopyright} Experimental Oncology, 2015.",

year = "2015",

month = dec,

doi = "10.31768/2312-8852.2015.37(4):292-294",

language = "English",

volume = "37",

pages = "292--294",

journal = "Experimental Oncology",

issn = "1812-9269",

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number = "4",

}

TY - JOUR

T1 - Impact of KRAS variant rs61764370 on breast cancer morbidity

AU - Ustinova, M.

AU - Daneberga, Z.

AU - Bērziņa, D.

AU - Nakazawa-Miklaševiča, M.

AU - Maksimenko, J.

AU - Gardovskis, J.

AU - Miklaševičs, E.

PY - 2015/12

Y1 - 2015/12

N2 - Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3' UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates.

AB - Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3' UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates.

KW - Breast cancer

KW - KRAS variant

KW - Predisposing factor

KW - Rs61764370

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U2 - 10.31768/2312-8852.2015.37(4):292-294

DO - 10.31768/2312-8852.2015.37(4):292-294

M3 - Article

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AN - SCOPUS:84953388004

SN - 1812-9269

VL - 37

SP - 292

EP - 294

JO - Experimental Oncology

JF - Experimental Oncology

IS - 4

ER -

Impact of KRAS variant rs61764370 on breast cancer morbidity

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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