Impact of Polymorphism in the b2-Receptor Gene on the Metabolic Response to Epinephrine After Repeated Hypoglycemia

Kim Z. Rokamp; Flemming Dela; Niels H. Secher; Lars Grønlykke; Birger Thorsteinsson; Ulrik Pedersen-Bjergaard

doi:10.2337/db22-0718

Impact of Polymorphism in the b₂-Receptor Gene on the Metabolic Response to Epinephrine After Repeated Hypoglycemia

Kim Z. Rokamp (Corresponding Author), Flemming Dela, Niels H. Secher, Lars Grønlykke, Birger Thorsteinsson, Ulrik Pedersen-Bjergaard

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Abstract

The b₂-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the b₂-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Twenty-five healthy men selected according to ADRB2 genotype being homozygous for either Gly16 (GG) (n = 12) or Arg16 (AA) (n = 13) participated in 4 trial days (D1–4): D1_pre and D4_post with epinephrine 0.06 lg kg²¹. min²¹ infusion and D2_hypo1–2 and D3_hypo3 with three periods of hypoglycemia by an insulin-glucose clamp. At D1_pre,theinsulin(mean±SEMofareaunderthecurve 44 ± 8 vs. 93 ± 13 pmol. L²¹ h; P = 0.0051), glycerol (79 ± 12 vs. 115 ± 14 lmol. L²¹ h; P = 0.041), and free fatty acid (724 ± 96 vs. 1,113 ± 140 lmol. L²¹ h; P = 0.033) responses to epinephrine were decreased in AA participants compared with GG participants but without a difference in glucose response. There were no differences in response to epinephrine between genotype groups after repetitive hypoglycemia at D4_post. The metabolic substrate response to epinephrine was decreased in AA participants compared with GG participants but without a difference between genotype groups after repetitive hypoglycemia.

Original language	English
Pages (from-to)	728-734
Number of pages	7
Journal	Diabetes
Volume	72
Issue number	6
DOIs	https://doi.org/10.2337/db22-0718
Publication status	Published - Jun 2023
Externally published	Yes

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/db22-0718Licence: CC BY

Impact of Polymorphism in the b2-Receptor GeneFinal published version, 933 KBLicence: CC BY

Cite this

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title = "Impact of Polymorphism in the b2-Receptor Gene on the Metabolic Response to Epinephrine After Repeated Hypoglycemia",

abstract = "The b2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the b2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Twenty-five healthy men selected according to ADRB2 genotype being homozygous for either Gly16 (GG) (n = 12) or Arg16 (AA) (n = 13) participated in 4 trial days (D1–4): D1pre and D4post with epinephrine 0.06 lg kg21. min21 infusion and D2hypo1–2 and D3hypo3 with three periods of hypoglycemia by an insulin-glucose clamp. At D1pre,theinsulin(mean±SEMofareaunderthecurve 44 ± 8 vs. 93 ± 13 pmol. L21 h; P = 0.0051), glycerol (79 ± 12 vs. 115 ± 14 lmol. L21 h; P = 0.041), and free fatty acid (724 ± 96 vs. 1,113 ± 140 lmol. L21 h; P = 0.033) responses to epinephrine were decreased in AA participants compared with GG participants but without a difference in glucose response. There were no differences in response to epinephrine between genotype groups after repetitive hypoglycemia at D4post. The metabolic substrate response to epinephrine was decreased in AA participants compared with GG participants but without a difference between genotype groups after repetitive hypoglycemia.",

author = "Rokamp, {Kim Z.} and Flemming Dela and Secher, {Niels H.} and Lars Gr{\o}nlykke and Birger Thorsteinsson and Ulrik Pedersen-Bjergaard",

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T1 - Impact of Polymorphism in the b2-Receptor Gene on the Metabolic Response to Epinephrine After Repeated Hypoglycemia

AU - Rokamp, Kim Z.

AU - Dela, Flemming

AU - Secher, Niels H.

AU - Grønlykke, Lars

AU - Thorsteinsson, Birger

AU - Pedersen-Bjergaard, Ulrik

PY - 2023/6

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N2 - The b2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the b2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Twenty-five healthy men selected according to ADRB2 genotype being homozygous for either Gly16 (GG) (n = 12) or Arg16 (AA) (n = 13) participated in 4 trial days (D1–4): D1pre and D4post with epinephrine 0.06 lg kg21. min21 infusion and D2hypo1–2 and D3hypo3 with three periods of hypoglycemia by an insulin-glucose clamp. At D1pre,theinsulin(mean±SEMofareaunderthecurve 44 ± 8 vs. 93 ± 13 pmol. L21 h; P = 0.0051), glycerol (79 ± 12 vs. 115 ± 14 lmol. L21 h; P = 0.041), and free fatty acid (724 ± 96 vs. 1,113 ± 140 lmol. L21 h; P = 0.033) responses to epinephrine were decreased in AA participants compared with GG participants but without a difference in glucose response. There were no differences in response to epinephrine between genotype groups after repetitive hypoglycemia at D4post. The metabolic substrate response to epinephrine was decreased in AA participants compared with GG participants but without a difference between genotype groups after repetitive hypoglycemia.

AB - The b2-receptor mediates the metabolic response to epinephrine. This study investigates the impact of the b2-receptor gene (ADRB2) polymorphism Gly16Arg on the metabolic response to epinephrine before and after repetitive hypoglycemia. Twenty-five healthy men selected according to ADRB2 genotype being homozygous for either Gly16 (GG) (n = 12) or Arg16 (AA) (n = 13) participated in 4 trial days (D1–4): D1pre and D4post with epinephrine 0.06 lg kg21. min21 infusion and D2hypo1–2 and D3hypo3 with three periods of hypoglycemia by an insulin-glucose clamp. At D1pre,theinsulin(mean±SEMofareaunderthecurve 44 ± 8 vs. 93 ± 13 pmol. L21 h; P = 0.0051), glycerol (79 ± 12 vs. 115 ± 14 lmol. L21 h; P = 0.041), and free fatty acid (724 ± 96 vs. 1,113 ± 140 lmol. L21 h; P = 0.033) responses to epinephrine were decreased in AA participants compared with GG participants but without a difference in glucose response. There were no differences in response to epinephrine between genotype groups after repetitive hypoglycemia at D4post. The metabolic substrate response to epinephrine was decreased in AA participants compared with GG participants but without a difference between genotype groups after repetitive hypoglycemia.

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