Implication of Human Parvoviruses in Aetiology of Meningitis and Meningoencephalitis

Anna Terentjeva (Coresponding Author), Modra Murovska (Scientific Advisor), Anda Vilmane (Scientific Advisor), Santa Rasa (Scientific Advisor), Zaiga Nora-Krūkle (Scientific Advisor), Normunds Sūna (Scientific Advisor)

Research output: Contribution to conferenceAbstractpeer-review

6 Downloads (Pure)


Objectives. For significant number of clinical cases of viral meningitis and
meningoencephalitis no aetiological agent is revealed. The aim of the study is to evaluate
the implication of human parvovirus B19 (B19V), human bocaviruses (HBoVs) and human
parvovirus 4 (hPARV4) in the development of mentioned neurological disorders.
Materials and methods. To determine the presence of HBoVs, B19V and hPARV4
genomic sequences in peripheral blood, cell free blood plasma and/or cerebrospinal fluid (CSF)
DNA samples of patients with meningitis or meningoencephalitis (n = 42) and blood donors
(BD) (n = 50) nPCRs targeting hPARV4 VP2, B19V NS1, HBoV1 NS1 and HBoV1-4 VP1/2 protein
genes were used. Information about patients’ demographics, clinical diagnoses, duration of
hospitalization and outcome, symptoms, results of blood tests, microbiological tests and CSF
analysis were retrospectively reviewed from the clinical data. IBM SPSS v22 and GraphPad
Prism 8.0 were used for data analysis.
Results. In total HBoV1-4 DNA was found in 52.4 % of patients and 28.0 % of BD
(p = 0.0199), B19V genomic sequence – in 16.7 % of patients and 6.0 % of BD (p = 0.1769),
respectively. hPARV4 genomic sequence was not detected in any of the patients’ or BD DNA
samples. Active parvoviruses infection defined as the presence of viral genomic sequences in
patients’ CSF and/or cell-free blood plasma DNA, was found in 15 (35.7 %) patients. Headache
(p = 0.01), more intense headache (p = 0.01), fatigue (p = 0.03), disorientation (p = 0.004) and
difficulties to concentrate (p = 0.03) were significantly more often present in patients with
active parvoviruses infection in comparison to patients with active infection caused by other
confirmed pathogens.
Conclusion. This is the first study showing the presence of HBoVs in adult patients with
neurological disorders as well as in blood donors in Latvia. HBoVs and B19V affect clinical
manifestations of meningitis and meningoencephalitis therefore might be one of the causative
agents of these particular disorders.


  • Human parvoviruses
  • Meningitis
  • Meningoencephalitis

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


Dive into the research topics of 'Implication of Human Parvoviruses in Aetiology of Meningitis and Meningoencephalitis'. Together they form a unique fingerprint.

Cite this