IMPROVED LVO FIRST-PASS EFFECT WITH PRECISE CYCLIC ASPIRATION:  EARLY EXPERIENCE WITH THE RAPIDPULSETM SYSTEM

Raul   Nogueira; Gyula  Gal; José Ignacio Gallego; Francisco Mont'alverne; Serdar  Geyik; Kārlis Kupčs; Federico Ballenilla; Carlos Domínguez   Rodríguez; Giorgio   Barbieri; Eduardo  Barcena; Josã Olmedo; Jose Carlos   Rayon-Aledo; Anabel   Diaz; Fernando Sánchez   Blanco; Arsida   Bajrami; Eren  Erdem; Özgür Zülfükar   Ertuğrul; Fabrício Oliveira  Lima; Felipe  Rocha; George Mendes; Alessandra Braga Cruz Guedes   de Morais; Henrique  Silva; Hellen  Homem; Diego   Bandeira; José Bezerra; Lidemarcks Irineu   Andrade; Anderson   de Lucena; Carmen Serna  Candel; Helmuts Kidikas; Jānis Vētra; Antonio  Sagredo

IMPROVED LVO FIRST-PASS EFFECT WITH PRECISE CYCLIC ASPIRATION: EARLY EXPERIENCE WITH THE RAPIDPULSETM SYSTEM

Raul Nogueira, Gyula Gal, José Ignacio Gallego, Francisco Mont'alverne, Serdar Geyik, Kārlis Kupčs, Federico Ballenilla, Carlos Domínguez Rodríguez, Giorgio Barbieri, Eduardo Barcena, Josã Olmedo, Jose Carlos Rayon-Aledo, Anabel Diaz, Fernando Sánchez Blanco, Arsida Bajrami, Eren Erdem, Özgür Zülfükar Ertuğrul, Fabrício Oliveira Lima, Felipe Rocha, George MendesAlessandra Braga Cruz Guedes de Morais, Henrique Silva, Hellen Homem, Diego Bandeira, José Bezerra, Lidemarcks Irineu Andrade, Anderson de Lucena, Carmen Serna Candel, Helmuts Kidikas, Jānis Vētra, Antonio Sagredo

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Background and aims: First-pass effect (FPE) is associated with improved clinical outcomes in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, FPE is achieved in only 30-40% of patients with the current devices. The RapidPulseTM Cyclic Aspiration System (RP) is a novel technology consisting of a valve box that precisely cycles pressure from full to no vacuum multiple times per second adding kinetic energy to the suction forces. Initial clinical evaluation suggests that the system can achieve FPE rates in the 70% range. We aim to evaluate the RP as a frontline approach in LVOS.
Methods: Prospective, multicenter, open-label, core lab adjudicated, early experience of the RapidPulseTM System. Patients with LVOS involving anterior and/or posterior circulations within 24 hours from stroke onset, without evidence of ICAD and/or tandem occlusions, and amenable to treatment with the Medtronic React-71 aspiration catheter were eligible. The primary outcome was the rate of FPE (mTICI ⩾2c after one pass). Secondary outcomes included frontline technical success (mTICI ⩾2b after final pass with no rescue therapy), and incidence of vessel injury and/or vasospasm. The study will enroll up to 100 participants at 6 centers across Spain, Turkey, Denmark, Latvia and Brazil.
Results: As of December 2022, about two-thirds of the target enrollment has been achieved. Final results will be presented at the ESOC.
Conclusions: RapidPulse TM is a novel cyclic aspiration technology designed to achieve faster and better reperfusion in LVOS while significantly reducing disposable device costs. Additional larger studies are currently underway.

Original language	English
Article number	1811
Journal	European Stroke Journal
Volume	8
Issue number	2, Suppl.
Publication status	Published - May 2023
Externally published	Yes
Event	9th European Stroke Organisation Conference - Munich, Germany Duration: 24 May 2023 → 26 May 2023 Conference number: 9 https://eso-stroke.org/meetings/eso-wso-conference/

Keywords*

Stroke

Field of Science*

3.2 Clinical medicine

Publication Type*

3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

Access to Document

http://10.1177/23969873231174267Licence: Unspecified

Cite this

Nogueira, R., Gal, G., Gallego, J. I., Mont'alverne, F., Geyik, S., Kupčs, K., Ballenilla, F., Rodríguez, C. D., Barbieri, G., Barcena, E., Olmedo, J., Rayon-Aledo, J. C., Diaz, A., Blanco, F. S., Bajrami, A., Erdem, E., Ertuğrul, Ö. Z., Lima, F. O., Rocha, F., ... Sagredo, A. (2023). IMPROVED LVO FIRST-PASS EFFECT WITH PRECISE CYCLIC ASPIRATION: EARLY EXPERIENCE WITH THE RAPIDPULSETM SYSTEM. European Stroke Journal, 8(2, Suppl.), Article 1811. http://10.1177/23969873231174267

@article{3be7b88ec4ad42c09cd15f21112da770,

title = "IMPROVED LVO FIRST-PASS EFFECT WITH PRECISE CYCLIC ASPIRATION: EARLY EXPERIENCE WITH THE RAPIDPULSETM SYSTEM",

abstract = "Background and aims: First-pass effect (FPE) is associated with improved clinical outcomes in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, FPE is achieved in only 30-40% of patients with the current devices. The RapidPulseTM Cyclic Aspiration System (RP) is a novel technology consisting of a valve box that precisely cycles pressure from full to no vacuum multiple times per second adding kinetic energy to the suction forces. Initial clinical evaluation suggests that the system can achieve FPE rates in the 70% range. We aim to evaluate the RP as a frontline approach in LVOS.Methods: Prospective, multicenter, open-label, core lab adjudicated, early experience of the RapidPulseTM System. Patients with LVOS involving anterior and/or posterior circulations within 24 hours from stroke onset, without evidence of ICAD and/or tandem occlusions, and amenable to treatment with the Medtronic React-71 aspiration catheter were eligible. The primary outcome was the rate of FPE (mTICI ⩾2c after one pass). Secondary outcomes included frontline technical success (mTICI ⩾2b after final pass with no rescue therapy), and incidence of vessel injury and/or vasospasm. The study will enroll up to 100 participants at 6 centers across Spain, Turkey, Denmark, Latvia and Brazil.Results: As of December 2022, about two-thirds of the target enrollment has been achieved. Final results will be presented at the ESOC.Conclusions: RapidPulse TM is a novel cyclic aspiration technology designed to achieve faster and better reperfusion in LVOS while significantly reducing disposable device costs. Additional larger studies are currently underway.",

keywords = "Stroke",

author = "Raul Nogueira and Gyula Gal and Gallego, {Jos{\'e} Ignacio} and Francisco Mont'alverne and Serdar Geyik and Kārlis Kup{\v c}s and Federico Ballenilla and Rodr{\'i}guez, {Carlos Dom{\'i}nguez} and Giorgio Barbieri and Eduardo Barcena and Jos{\~a} Olmedo and Rayon-Aledo, {Jose Carlos} and Anabel Diaz and Blanco, {Fernando S{\'a}nchez} and Arsida Bajrami and Eren Erdem and Ertuğrul, {{\"O}zg{\"u}r Z{\"u}lf{\"u}kar} and Lima, {Fabr{\'i}cio Oliveira} and Felipe Rocha and George Mendes and {de Morais}, {Alessandra Braga Cruz Guedes} and Henrique Silva and Hellen Homem and Diego Bandeira and Jos{\'e} Bezerra and Andrade, {Lidemarcks Irineu} and {de Lucena}, Anderson and Candel, {Carmen Serna} and Helmuts Kidikas and Jānis Vētra and Antonio Sagredo",

year = "2023",

month = may,

language = "English",

volume = "8",

journal = "European Stroke Journal",

issn = "2396-9873",

publisher = "SAGE Publications Inc.",

number = "2, Suppl.",

note = "9th European Stroke Organisation Conference, ESOC 2023 ; Conference date: 24-05-2023 Through 26-05-2023",

url = "https://eso-stroke.org/meetings/eso-wso-conference/",

}

Nogueira, R, Gal, G, Gallego, JI, Mont'alverne, F, Geyik, S, Kupčs, K, Ballenilla, F, Rodríguez, CD, Barbieri, G, Barcena, E, Olmedo, J, Rayon-Aledo, JC, Diaz, A, Blanco, FS, Bajrami, A, Erdem, E, Ertuğrul, ÖZ, Lima, FO, Rocha, F, Mendes, G, de Morais, ABCG, Silva, H, Homem, H, Bandeira, D, Bezerra, J, Andrade, LI, de Lucena, A, Candel, CS, Kidikas, H, Vētra, J & Sagredo, A 2023, 'IMPROVED LVO FIRST-PASS EFFECT WITH PRECISE CYCLIC ASPIRATION: EARLY EXPERIENCE WITH THE RAPIDPULSETM SYSTEM', European Stroke Journal, vol. 8, no. 2, Suppl., 1811. <http://10.1177/23969873231174267>

TY - JOUR

T1 - IMPROVED LVO FIRST-PASS EFFECT WITH PRECISE CYCLIC ASPIRATION

T2 - 9th European Stroke Organisation Conference

AU - Nogueira, Raul

AU - Gal, Gyula

AU - Gallego, José Ignacio

AU - Mont'alverne, Francisco

AU - Geyik, Serdar

AU - Kupčs, Kārlis

AU - Ballenilla, Federico

AU - Rodríguez, Carlos Domínguez

AU - Barbieri, Giorgio

AU - Barcena, Eduardo

AU - Olmedo, Josã

AU - Rayon-Aledo, Jose Carlos

AU - Diaz, Anabel

AU - Blanco, Fernando Sánchez

AU - Bajrami, Arsida

AU - Erdem, Eren

AU - Ertuğrul, Özgür Zülfükar

AU - Lima, Fabrício Oliveira

AU - Rocha, Felipe

AU - Mendes, George

AU - de Morais, Alessandra Braga Cruz Guedes

AU - Silva, Henrique

AU - Homem, Hellen

AU - Bandeira, Diego

AU - Bezerra, José

AU - Andrade, Lidemarcks Irineu

AU - de Lucena, Anderson

AU - Candel, Carmen Serna

AU - Kidikas, Helmuts

AU - Vētra, Jānis

AU - Sagredo, Antonio

N1 - Conference code: 9

PY - 2023/5

Y1 - 2023/5

N2 - Background and aims: First-pass effect (FPE) is associated with improved clinical outcomes in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, FPE is achieved in only 30-40% of patients with the current devices. The RapidPulseTM Cyclic Aspiration System (RP) is a novel technology consisting of a valve box that precisely cycles pressure from full to no vacuum multiple times per second adding kinetic energy to the suction forces. Initial clinical evaluation suggests that the system can achieve FPE rates in the 70% range. We aim to evaluate the RP as a frontline approach in LVOS.Methods: Prospective, multicenter, open-label, core lab adjudicated, early experience of the RapidPulseTM System. Patients with LVOS involving anterior and/or posterior circulations within 24 hours from stroke onset, without evidence of ICAD and/or tandem occlusions, and amenable to treatment with the Medtronic React-71 aspiration catheter were eligible. The primary outcome was the rate of FPE (mTICI ⩾2c after one pass). Secondary outcomes included frontline technical success (mTICI ⩾2b after final pass with no rescue therapy), and incidence of vessel injury and/or vasospasm. The study will enroll up to 100 participants at 6 centers across Spain, Turkey, Denmark, Latvia and Brazil.Results: As of December 2022, about two-thirds of the target enrollment has been achieved. Final results will be presented at the ESOC.Conclusions: RapidPulse TM is a novel cyclic aspiration technology designed to achieve faster and better reperfusion in LVOS while significantly reducing disposable device costs. Additional larger studies are currently underway.

AB - Background and aims: First-pass effect (FPE) is associated with improved clinical outcomes in mechanical thrombectomy (MT) for large vessel occlusion strokes (LVOS). However, FPE is achieved in only 30-40% of patients with the current devices. The RapidPulseTM Cyclic Aspiration System (RP) is a novel technology consisting of a valve box that precisely cycles pressure from full to no vacuum multiple times per second adding kinetic energy to the suction forces. Initial clinical evaluation suggests that the system can achieve FPE rates in the 70% range. We aim to evaluate the RP as a frontline approach in LVOS.Methods: Prospective, multicenter, open-label, core lab adjudicated, early experience of the RapidPulseTM System. Patients with LVOS involving anterior and/or posterior circulations within 24 hours from stroke onset, without evidence of ICAD and/or tandem occlusions, and amenable to treatment with the Medtronic React-71 aspiration catheter were eligible. The primary outcome was the rate of FPE (mTICI ⩾2c after one pass). Secondary outcomes included frontline technical success (mTICI ⩾2b after final pass with no rescue therapy), and incidence of vessel injury and/or vasospasm. The study will enroll up to 100 participants at 6 centers across Spain, Turkey, Denmark, Latvia and Brazil.Results: As of December 2022, about two-thirds of the target enrollment has been achieved. Final results will be presented at the ESOC.Conclusions: RapidPulse TM is a novel cyclic aspiration technology designed to achieve faster and better reperfusion in LVOS while significantly reducing disposable device costs. Additional larger studies are currently underway.

KW - Stroke

UR - https://journals.sagepub.com/doi/full/10.1177/23969873231174267

M3 - Meeting Abstract

SN - 2396-9873

VL - 8

JO - European Stroke Journal

JF - European Stroke Journal

IS - 2, Suppl.

M1 - 1811

Y2 - 24 May 2023 through 26 May 2023

ER -