TY - JOUR
T1 - In-situ crosslinked hydrogel based on amidated pectin/oxidized chitosan as potential wound dressing for skin repairing
AU - Amirian, Jhaleh
AU - Zeng, Yue
AU - Shekh, Mehdihasan I.
AU - Sharma, Gaurav
AU - Stadler, Florian J.
AU - Song, Jun
AU - Du, Bing
AU - Zhu, Yanxia
N1 - Funding Information:
This research was funded by Shenzhen Fundamental Research Funds ( JCYJ20170302145500980 , JCYJ20170818100526471 , KQJSCX20180328095512554 ), Medical Scientific Research Foundation of Guangdong Province ( A2018555 ), Nanshan District Key Lab for Biopolymers and Safety Evaluation ( KC2014ZDZJ0001A ) and Shenzhen Sci & Tech research grant ( ZDSYS201507141105130 ). The authors also would like to sincerely acknowledge the Instrumental Analysis Center of Shenzhen University for access to the multiphoton microscope.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Hydrogel can provide a favorable moisture environment for skin wound healing. In this study, a novel in-situ crosslinked injectable hydrogel was prepared using the water-soluble amidated pectin (AP) and oxidized chitosan (OC) through Schiff-base reaction without any chemical crosslinker. The influence of AP content on the properties of the hydrogel was systemically investigated. It showed that gelation time, pore structure, swelling capability and degradability of the hydrogel can be tuned by varying the content of amine and aldehyde groups from AP and OC. All the porous hydrogels with various AP contents (65%, 70%, and 80%) presented desirable gelation time, swelling property, high hemocompatibility and biocompatibility. Particularly, AP-OC-65 hydrogel presented superior swelling capability and better hemo- and bio-compatibility, owing to more residual amine sites in the hydrogel. Therefore, the injectable AP-OC-65 hydrogel has a greater potential for application to wound dressing or skin substitute.
AB - Hydrogel can provide a favorable moisture environment for skin wound healing. In this study, a novel in-situ crosslinked injectable hydrogel was prepared using the water-soluble amidated pectin (AP) and oxidized chitosan (OC) through Schiff-base reaction without any chemical crosslinker. The influence of AP content on the properties of the hydrogel was systemically investigated. It showed that gelation time, pore structure, swelling capability and degradability of the hydrogel can be tuned by varying the content of amine and aldehyde groups from AP and OC. All the porous hydrogels with various AP contents (65%, 70%, and 80%) presented desirable gelation time, swelling property, high hemocompatibility and biocompatibility. Particularly, AP-OC-65 hydrogel presented superior swelling capability and better hemo- and bio-compatibility, owing to more residual amine sites in the hydrogel. Therefore, the injectable AP-OC-65 hydrogel has a greater potential for application to wound dressing or skin substitute.
KW - chitosan
KW - injectable hydrogel
KW - pectin
KW - Schiff-base reaction
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85090962961&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2020.117005
DO - 10.1016/j.carbpol.2020.117005
M3 - Article
C2 - 33142572
AN - SCOPUS:85090962961
SN - 0144-8617
VL - 251
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 117005
ER -