In vitro evaluation of osteoblast cell behavior and antimicrobial properties of biphasic calcium phosphate ceramics

D. Loca, A. Dubnika, A. Reinis, N. Romancikova

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Calcium phosphate ceramic materials in form of hydroxylapatite (HAp) and β-tricalcium phosphate (TCP) are good candidates for bone substitution and regeneration. Majority of methods used for biphasic calcium phosphate (mixture of HAp and TCP) preparation includes synthesis of calcium deficient apatite, not so often mechanical mixing of HAp and TCP is applied. The aim of this work was to evaluate the effect of HAp/TCP ratio as well as the impact of biphasic calcium phosphate (BCP) preparation technique on osteoblast cell behavior and ceramic antimicrobial properties. Results showed that BCP composite samples supported much higher proliferation rate of osteoblast cells as those of pure HAp or TCP. The best result was observed for BCP samples with HAp/TCP ratio 60/40. BCP preparation technique significantly does not affect the cell attachment on the surface of BCP samples, while influence on colonization intensity of bacteria was observed. Results indicated that the use of pure HAp or BCP ceramics as implant materials can cause less inflammatory risks compared to the pure TCP ceramics.

Original languageEnglish
Title of host publicationInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012
EditorsYuri Dekhtyar, Alexei Katashev, Linda Lancere
Place of PublicationRīga
PublisherSpringer
Pages186-189
Number of pages4
ISBN (Electronic) 978-3-642-34197-7
ISBN (Print)9783642341960
DOIs
Publication statusPublished - 2013
EventInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012 - Riga, Latvia
Duration: 10 Oct 201212 Oct 2012

Publication series

NameIFMBE Proceedings
Volume38 IFMBE
ISSN (Print)1680-0737

Conference

ConferenceInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012
Country/TerritoryLatvia
CityRiga
Period10/10/1212/10/12

Keywords*

  • β-tricalcium phosphate
  • bioceramics
  • biphasic calcium phosphate ceramics
  • hydroxyapatite

Field of Science*

  • 2.6 Medical engineering
  • 2.5 Materials engineering

Publication Type*

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

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