Abstract
The present study addresses the effect of incorporation of alginate (ALG)-hyaluronic acid (HA) microbeads into calcium phosphate cement (CPC) based injectable bone substitute system. The morphology, chemical structure, setting time, compressive strength, injectability, washout resistance and in-vivo biological performance of CPC and CPC/ALG-HA were examined. Addition of ALG-HA microbeads in CPC resulted in an increase in the injectability and washout resistance of CPC. In-vivo studies of CPC/ALG-HA showed an improved bone formation after 8 weeks compared to CPC. The percent bone healing efficiency of CPC/ALG-HA and CPC was 26.6 ± 0.6 and 21.4 ± 0.5, respectively. The results suggest that CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.
Original language | English |
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Article number | 127830 |
Number of pages | 5 |
Journal | Materials Letters |
Volume | 272 |
DOIs | |
Publication status | Published - 1 Aug 2020 |
Externally published | Yes |
Keywords*
- CPC
- ALG-HA
- Microbeads
- Cement
- Injectable bone substitute
Field of Science*
- 2.10 Nano-technology
- 1.4 Chemical sciences
- 2.5 Materials engineering
- 3.5 Other medical sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database