Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration

Jhaleh Amirian , Preeti Makkar, Gun Hee Lee, Kallyanashis Paul, Byong Taek Lee (Corresponding Author)

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The present study addresses the effect of incorporation of alginate (ALG)-hyaluronic acid (HA) microbeads into calcium phosphate cement (CPC) based injectable bone substitute system. The morphology, chemical structure, setting time, compressive strength, injectability, washout resistance and in-vivo biological performance of CPC and CPC/ALG-HA were examined. Addition of ALG-HA microbeads in CPC resulted in an increase in the injectability and washout resistance of CPC. In-vivo studies of CPC/ALG-HA showed an improved bone formation after 8 weeks compared to CPC. The percent bone healing efficiency of CPC/ALG-HA and CPC was 26.6 ± 0.6 and 21.4 ± 0.5, respectively. The results suggest that CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.
Original languageEnglish
Article number127830
Number of pages5
JournalMaterials Letters
Volume272
DOIs
Publication statusPublished - 1 Aug 2020
Externally publishedYes

Keywords*

  • CPC
  • ALG-HA
  • Microbeads
  • Cement
  • Injectable bone substitute

Field of Science*

  • 2.10 Nano-technology
  • 1.4 Chemical sciences
  • 2.5 Materials engineering
  • 3.5 Other medical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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