Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration

Jhaleh Amirian; Preeti Makkar; Gun Hee Lee; Kallyanashis Paul; Byong Taek Lee

doi:10.1016/j.matlet.2020.127830

Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration

Jhaleh Amirian
, Preeti Makkar
, Gun Hee Lee
, Kallyanashis Paul
, Byong Taek Lee (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The present study addresses the effect of incorporation of alginate (ALG)-hyaluronic acid (HA) microbeads into calcium phosphate cement (CPC) based injectable bone substitute system. The morphology, chemical structure, setting time, compressive strength, injectability, washout resistance and in-vivo biological performance of CPC and CPC/ALG-HA were examined. Addition of ALG-HA microbeads in CPC resulted in an increase in the injectability and washout resistance of CPC. In-vivo studies of CPC/ALG-HA showed an improved bone formation after 8 weeks compared to CPC. The percent bone healing efficiency of CPC/ALG-HA and CPC was 26.6 ± 0.6 and 21.4 ± 0.5, respectively. The results suggest that CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.

Original language	English
Article number	127830
Number of pages	5
Journal	Materials Letters
Volume	272
DOIs	https://doi.org/10.1016/j.matlet.2020.127830
Publication status	Published - 1 Aug 2020
Externally published	Yes

Keywords*

CPC
ALG-HA
Microbeads
Cement
Injectable bone substitute

Field of Science*

2.1 Civil engineering
2.5 Materials engineering
1.4 Chemical sciences
3.5 Other medical sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.matlet.2020.127830

Cite this

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title = "Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration",

abstract = "The present study addresses the effect of incorporation of alginate (ALG)-hyaluronic acid (HA) microbeads into calcium phosphate cement (CPC) based injectable bone substitute system. The morphology, chemical structure, setting time, compressive strength, injectability, washout resistance and in-vivo biological performance of CPC and CPC/ALG-HA were examined. Addition of ALG-HA microbeads in CPC resulted in an increase in the injectability and washout resistance of CPC. In-vivo studies of CPC/ALG-HA showed an improved bone formation after 8 weeks compared to CPC. The percent bone healing efficiency of CPC/ALG-HA and CPC was 26.6 ± 0.6 and 21.4 ± 0.5, respectively. The results suggest that CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.",

keywords = "CPC, ALG-HA, Microbeads, Cement, Injectable bone substitute",

author = "Jhaleh Amirian and Preeti Makkar and Lee, \{Gun Hee\} and Kallyanashis Paul and Lee, \{Byong Taek\}",

year = "2020",

month = aug,

day = "1",

doi = "10.1016/j.matlet.2020.127830",

language = "English",

volume = "272",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration

AU - Amirian , Jhaleh

AU - Makkar, Preeti

AU - Lee, Gun Hee

AU - Paul, Kallyanashis

AU - Lee, Byong Taek

PY - 2020/8/1

Y1 - 2020/8/1

N2 - The present study addresses the effect of incorporation of alginate (ALG)-hyaluronic acid (HA) microbeads into calcium phosphate cement (CPC) based injectable bone substitute system. The morphology, chemical structure, setting time, compressive strength, injectability, washout resistance and in-vivo biological performance of CPC and CPC/ALG-HA were examined. Addition of ALG-HA microbeads in CPC resulted in an increase in the injectability and washout resistance of CPC. In-vivo studies of CPC/ALG-HA showed an improved bone formation after 8 weeks compared to CPC. The percent bone healing efficiency of CPC/ALG-HA and CPC was 26.6 ± 0.6 and 21.4 ± 0.5, respectively. The results suggest that CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.

AB - The present study addresses the effect of incorporation of alginate (ALG)-hyaluronic acid (HA) microbeads into calcium phosphate cement (CPC) based injectable bone substitute system. The morphology, chemical structure, setting time, compressive strength, injectability, washout resistance and in-vivo biological performance of CPC and CPC/ALG-HA were examined. Addition of ALG-HA microbeads in CPC resulted in an increase in the injectability and washout resistance of CPC. In-vivo studies of CPC/ALG-HA showed an improved bone formation after 8 weeks compared to CPC. The percent bone healing efficiency of CPC/ALG-HA and CPC was 26.6 ± 0.6 and 21.4 ± 0.5, respectively. The results suggest that CPC/ALG-HA could be used as a potential injectable bone substitute for improved bone regeneration.

KW - CPC

KW - ALG-HA

KW - Microbeads

KW - Cement

KW - Injectable bone substitute

UR - https://www.scopus.com/pages/publications/85083632533

U2 - 10.1016/j.matlet.2020.127830

DO - 10.1016/j.matlet.2020.127830

M3 - Article

SN - 0167-577X

VL - 272

JO - Materials Letters

JF - Materials Letters

M1 - 127830

ER -

Incorporation of alginate-hyaluronic acid microbeads in injectable calcium phosphate cement for improved bone regeneration

Abstract

Keywords*

Field of Science*

Publication Type*

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