TY - JOUR
T1 - Inherited variants in the MC1R gene and survival from cutaneous melanoma
T2 - A BioGenoMEL study
AU - Davies, John R.
AU - Randerson-Moor, Juliette
AU - Kukalizch, Kairen
AU - Harland, Mark
AU - Kumar, Rajiv
AU - Madhusudan, Srinivasan
AU - Nagore, Eduardo
AU - Hansson, Johan
AU - Höiom, Veronica
AU - Ghiorzo, Paola
AU - Gruis, Nelleke A.
AU - Kanetsky, Peter A.
AU - Wendt, Judith
AU - Pjanova, Dace
AU - Puig, Susana
AU - Saiag, Philippe
AU - Schadendorf, Dirk
AU - Soufir, Nadem
AU - Okamoto, Ichiro
AU - Affleck, Paul
AU - García-Casado, Zaida
AU - Ogbah, Zighereda
AU - Ozola, Aija
AU - Queirolo, Paola
AU - Sucker, Antje
AU - Barrett, Jennifer H.
AU - van Doorn, Remco
AU - Bishop, D. Timothy
AU - Newton-Bishop, Julia
PY - 2012/5
Y1 - 2012/5
N2 - Inherited MC1R variants modulate MITF transcription factor signaling, which in turn affects tumor cell proliferation, apoptosis, and DNA repair. The aim of this BioGenoMEL collaborative study in 10 melanoma cohorts was to test the hypothesis that inherited variants thereby moderate survival expectation. A survival analysis in the largest cohort (Leeds) was carried out adjusting for factors known to impact on survival. The results were then compared with data from nine smaller cohorts. The absence of any consensus MC1R alleles was associated with a significantly lower risk of death in the Leeds set (HR, 0.64; 95% CI, 0.46-0.89) and overall in the 10 data sets (HR, 0.78; 95% CI, 0.65-0.94) with some support from the nine smaller data sets considered together (HR, 0.83; 95% CI, 0.67-1.04). The data are suggestive of a survival benefit for inherited MC1R variants in melanoma patients.
AB - Inherited MC1R variants modulate MITF transcription factor signaling, which in turn affects tumor cell proliferation, apoptosis, and DNA repair. The aim of this BioGenoMEL collaborative study in 10 melanoma cohorts was to test the hypothesis that inherited variants thereby moderate survival expectation. A survival analysis in the largest cohort (Leeds) was carried out adjusting for factors known to impact on survival. The results were then compared with data from nine smaller cohorts. The absence of any consensus MC1R alleles was associated with a significantly lower risk of death in the Leeds set (HR, 0.64; 95% CI, 0.46-0.89) and overall in the 10 data sets (HR, 0.78; 95% CI, 0.65-0.94) with some support from the nine smaller data sets considered together (HR, 0.83; 95% CI, 0.67-1.04). The data are suggestive of a survival benefit for inherited MC1R variants in melanoma patients.
KW - Forest plot
KW - MC1R
KW - Melanoma
KW - MITF
KW - Survival analysis
UR - http://www.scopus.com/inward/record.url?scp=84865334617&partnerID=8YFLogxK
U2 - 10.1111/j.1755-148X.2012.00982.x
DO - 10.1111/j.1755-148X.2012.00982.x
M3 - Article
C2 - 22325793
AN - SCOPUS:84865334617
SN - 1755-1471
VL - 25
SP - 384
EP - 394
JO - Pigment Cell and Melanoma Research
JF - Pigment Cell and Melanoma Research
IS - 3
ER -
