Initial findings in retinoblastoma patients

Sandra Ose, Bernhard Steiner, Andreas Wedrich, Christoph Schwab, Petra Ritter-Sovinz

Research output: Contribution to conferenceAbstractpeer-review


The purpose of the study is to access the initial ocular and general findings in children treated for retinoblastoma and compare to the treatment outcome. A retrospective study of all the retinoblastoma patients treated in LKH University Hospital Graz, Austria was conducted. Data were assessed using IBM-SPSS (Version 26). The 147 eyes of 101 patients 45 (44.6%), female and 56 (55.4%) male affected by retinoblastoma were analyzed. Unilateral retinoblastoma was presented  in 54 (54%) patients, bilateral in 47 (47%) patients. Findings additionally to the tumor lesions at the first discovery were: intravitreal seeding n=31 (30.7%) tumor induced serous retinal detachment n=22 (21.8%), choroidal infiltration n=22 (21.8%), infiltration of the optic nerve n= 17 (16.8%), subretinal seeding of the tumor n=14 (13.9%), secondary rubeosis iridis n=9 (8.9%), secondary glaucoma n=6 (5.9%), scleral infiltration n=3 (3%), infiltration in anterior chamber n=3 (3%), optic nerve atrophy n=1 (1%) , epiretinal membrane n=1 (1%) , central neovascular membrane n=1 (1%) Affected eyes saved in 25 (25%) patients, 98 (97%) patients survived and no information of the outcome could be found in 2 patients (2%). Extraocular tumor spreading was found in 2 patients (orbital spreading and leptomeningeal metastases) 1 of these patients (1%) died.  Retinoblastoma survival ,with current therapy, is excellent in patients without extraocular tumor spreading. The presence of secondary ocular tumor findings did not influence patient’s survival. Extraocular spreading, that is is rarely seen in developed countries, is a life threatening condition and must be treated aggressively. 
Original languageEnglish
Publication statusPublished - 24 Mar 2021
Externally publishedYes
EventRSU Research week 2021: Knowledge for Use in Practice - Rīga, Latvia
Duration: 24 Mar 202126 Mar 2021


ConferenceRSU Research week 2021: Knowledge for Use in Practice
Abbreviated titleRW2021
Internet address

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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