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Abstract
Objectives*
Evaluate the effectiveness of contrast enhanced ultrasound (CEUS) in comparison to CT angiography (CTA) and superb microvascular imaging (SMI) for verification of atherosclerotic plaque instability.
Compare obtained multi-parametric data from US and CT with histological results.
Materials and Methods
During the prospective research, 89 patients underwent Doppler ultrasound examination. All consecutive pa- tients with atherosclerotic plaques and stenosis over 50% in the carotid arteries were enrolled for the study following SMI, CEUS and CTA. Plaque instability was assessed using each modality, with particular attention to neovascularization. For surgical treated patients also histological evaluation of the plaque was performed. Neovascularization was classified in three grades (no, Grade 1, Grade 2) after which statistical analysis was performed.
Results
• By performing CTA unstable plaques were found in 22 (24.7 %) patients.
• Using CEUS method neovascularization was detected in 46 (51.7%) plaques, 26 (29.2%) were grade 1
and 20 (22.5%) were grade 2 neovascularized. A statistically significant, strong correlation was found between the CEUS method and the results of histology (rs = 0.458; p = 0.0001) CEUS was the most sensitive method for evaluating plaque instability (80.56% sensitivity, 77.78% specificity, accuracy – 79.29%).
• SMI detected fewer neovascularized plaques (23 - 25.8%) compared to CEUS but correlated significantly with CEUS findings (rs = 0.669; p = 0.0001).
• CTA correlated with the maximum systolic rate (rs = 0.458, p = 0.001) and the diastolic systolic rate at the stenosis site (rs = 0.385, p = 0.004).
Conclusions
• CEUS method can show the amount of neovascularization within the plaque, determine vulnerability of the plaque, and has a high level of agreement with histological findings.
• CEUS and SMI have low diagnostic value in cases of calcified plaques.
• CEUS ir the most sensitive method for diagnosing neovascularization in an unstable plaque.
Evaluate the effectiveness of contrast enhanced ultrasound (CEUS) in comparison to CT angiography (CTA) and superb microvascular imaging (SMI) for verification of atherosclerotic plaque instability.
Compare obtained multi-parametric data from US and CT with histological results.
Materials and Methods
During the prospective research, 89 patients underwent Doppler ultrasound examination. All consecutive pa- tients with atherosclerotic plaques and stenosis over 50% in the carotid arteries were enrolled for the study following SMI, CEUS and CTA. Plaque instability was assessed using each modality, with particular attention to neovascularization. For surgical treated patients also histological evaluation of the plaque was performed. Neovascularization was classified in three grades (no, Grade 1, Grade 2) after which statistical analysis was performed.
Results
• By performing CTA unstable plaques were found in 22 (24.7 %) patients.
• Using CEUS method neovascularization was detected in 46 (51.7%) plaques, 26 (29.2%) were grade 1
and 20 (22.5%) were grade 2 neovascularized. A statistically significant, strong correlation was found between the CEUS method and the results of histology (rs = 0.458; p = 0.0001) CEUS was the most sensitive method for evaluating plaque instability (80.56% sensitivity, 77.78% specificity, accuracy – 79.29%).
• SMI detected fewer neovascularized plaques (23 - 25.8%) compared to CEUS but correlated significantly with CEUS findings (rs = 0.669; p = 0.0001).
• CTA correlated with the maximum systolic rate (rs = 0.458, p = 0.001) and the diastolic systolic rate at the stenosis site (rs = 0.385, p = 0.004).
Conclusions
• CEUS method can show the amount of neovascularization within the plaque, determine vulnerability of the plaque, and has a high level of agreement with histological findings.
• CEUS and SMI have low diagnostic value in cases of calcified plaques.
• CEUS ir the most sensitive method for diagnosing neovascularization in an unstable plaque.
| Original language | English |
|---|---|
| Pages | 128 - 128 |
| Number of pages | 1 |
| Publication status | Published - 28 Mar 2025 |
| Externally published | Yes |
| Event | RSU Research Week 2025: Knowledge for Use in Practice - Riga Stradiņš university, Riga, Latvia Duration: 26 Mar 2025 → 28 Mar 2025 https://rw2025.rsu.lv/conferences/knowledge-use-practice |
Conference
| Conference | RSU Research Week 2025: Knowledge for Use in Practice |
|---|---|
| Country/Territory | Latvia |
| City | Riga |
| Period | 26/03/25 → 28/03/25 |
| Other | Infections in the Development of Non-Communicable Diseases |
| Internet address |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
Fingerprint
Dive into the research topics of 'Integrative Analysis of Carotid Plaque Instability: Multimodal Ultrasound, CTA, and Histology in Focus.'. Together they form a unique fingerprint.Research output
- 1 Book
-
Rīga Stradiņš University International Research Conference on Medical and Health Care Sciences “Knowledge for Use in Practice”: Abstracts, 26-28 March, 2025
Rīga Stradiņš University, 2025, Rīga: Rīga Stradiņš University. 478 p.Research output: Book/Report › Book
Open Access