Interbirth interval is associated with childhood type 1 diabetes risk

Chris R. Cardwell; Jannet Svensson; Thomas Waldhoer; Johnny Ludvigsson; Vaiva Sadauskaite-Kuehne; Christine L. Roberts; Roger C. Parslow; Emma J. K. Wadsworth; Girts Brigis; Brone Urbonaite; Edith Schober; Gabriele Devoti; Constantin Ionescu-Tirgoviste; Carine E. de Beaufort; Gyula Soltesz; Chris C. Patterson

doi:10.2337/db11-1000

Interbirth interval is associated with childhood type 1 diabetes risk

Chris R. Cardwell, Jannet Svensson, Thomas Waldhoer, Johnny Ludvigsson, Vaiva Sadauskaite-Kuehne, Christine L. Roberts, Roger C. Parslow, Emma J. K. Wadsworth, Girts Brigis, Brone Urbonaite, Edith Schober, Gabriele Devoti, Constantin Ionescu-Tirgoviste, Carine E. de Beaufort, Gyula Soltesz, Chris C. Patterson

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Abstract

Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals β3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals β3 years.

Original language	English
Pages (from-to)	702-707
Number of pages	6
Journal	Diabetes
Volume	61
Issue number	3
DOIs	https://doi.org/10.2337/db11-1000 https://doi.org/10.2337/db11-1000
Publication status	Published - Mar 2012

Field of Science*

3.2 Clinical medicine
3.3 Health sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Interbirth Interval Is Associated With Childhood Type 1Final published version, 749 KB

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Cardwell, C. R., Svensson, J., Waldhoer, T., Ludvigsson, J., Sadauskaite-Kuehne, V., Roberts, C. L., Parslow, R. C., Wadsworth, E. J. K., Brigis, G., Urbonaite, B., Schober, E., Devoti, G., Ionescu-Tirgoviste, C., de Beaufort, C. E., Soltesz, G., & Patterson, C. C. (2012). Interbirth interval is associated with childhood type 1 diabetes risk. Diabetes, 61(3), 702-707. https://doi.org/10.2337/db11-1000, https://doi.org/10.2337/db11-1000

@article{4cb0bf0ce1c94ffd8396fe62b9fc9e42,

title = "Interbirth interval is associated with childhood type 1 diabetes risk",

abstract = "Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals β3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals β3 years.",

author = "Cardwell, {Chris R.} and Jannet Svensson and Thomas Waldhoer and Johnny Ludvigsson and Vaiva Sadauskaite-Kuehne and Roberts, {Christine L.} and Parslow, {Roger C.} and Wadsworth, {Emma J. K.} and Girts Brigis and Brone Urbonaite and Edith Schober and Gabriele Devoti and Constantin Ionescu-Tirgoviste and {de Beaufort}, {Carine E.} and Gyula Soltesz and Patterson, {Chris C.}",

year = "2012",

month = mar,

doi = "10.2337/db11-1000",

language = "English",

volume = "61",

pages = "702--707",

journal = "Diabetes",

issn = "0012-1797",

publisher = "American Diabetes Association Inc.",

number = "3",

}

Cardwell, CR, Svensson, J, Waldhoer, T, Ludvigsson, J, Sadauskaite-Kuehne, V, Roberts, CL, Parslow, RC, Wadsworth, EJK, Brigis, G, Urbonaite, B, Schober, E, Devoti, G, Ionescu-Tirgoviste, C, de Beaufort, CE, Soltesz, G & Patterson, CC 2012, 'Interbirth interval is associated with childhood type 1 diabetes risk', Diabetes, vol. 61, no. 3, pp. 702-707. https://doi.org/10.2337/db11-1000, https://doi.org/10.2337/db11-1000

TY - JOUR

T1 - Interbirth interval is associated with childhood type 1 diabetes risk

AU - Cardwell, Chris R.

AU - Svensson, Jannet

AU - Waldhoer, Thomas

AU - Ludvigsson, Johnny

AU - Sadauskaite-Kuehne, Vaiva

AU - Roberts, Christine L.

AU - Parslow, Roger C.

AU - Wadsworth, Emma J. K.

AU - Brigis, Girts

AU - Urbonaite, Brone

AU - Schober, Edith

AU - Devoti, Gabriele

AU - Ionescu-Tirgoviste, Constantin

AU - de Beaufort, Carine E.

AU - Soltesz, Gyula

AU - Patterson, Chris C.

PY - 2012/3

Y1 - 2012/3

N2 - Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals β3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals β3 years.

AB - Short interbirth interval has been associated with maternal complications and childhood autism and leukemia, possibly due to deficiencies in maternal micronutrients at conception or increased exposure to sibling infections. A possible association between interbirth interval and subsequent risk of childhood type 1 diabetes has not been investigated. A secondary analysis of 14 published observational studies of perinatal risk factors for type 1 diabetes was conducted. Risk estimates of diabetes by category of interbirth interval were calculated for each study. Random effects models were used to calculate pooled odds ratios (ORs) and investigate heterogeneity between studies. Overall, 2,787 children with type 1 diabetes were included. There was a reduction in the risk of childhood type 1 diabetes in children born to mothers after interbirth intervals β3 years compared with longer interbirth intervals (OR 0.82 [95% CI 0.72-0.93]). Adjustments for various potential confounders little altered this estimate. In conclusion, there was evidence of a 20% reduction in the risk of childhood diabetes in children born to mothers after interbirth intervals β3 years.

UR - https://diabetes.diabetesjournals.org/content/diabetes/61/3/702.full.pdf

U2 - 10.2337/db11-1000

DO - 10.2337/db11-1000

M3 - Article

C2 - 22315303

AN - SCOPUS:84857427454

SN - 0012-1797

VL - 61

SP - 702

EP - 707

JO - Diabetes

JF - Diabetes

IS - 3

ER -

Interbirth interval is associated with childhood type 1 diabetes risk

Abstract

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