Abstract
Interferon gamma (IFNg) production in whole peripheral blood (WPB) and mononuclear (MN) cell culture in acute hepatitis B (AHB) was compared. IFNg production was induced by phytogem agglutinin and measured in the cell supernatants of 14 AHB patients in the course of the disease. There were some up-regulating factors of IFNg production that probably operated in WPB culture: the presence of autoerythrocytes as well as the low content of monocytes. Autoserum regulated IFNg production in a stage-dependent way: it decreased IFNg activity at the bilirubin peak in hepatitis B infection, but not in convalescence. In contrast, we did not find a serum blocking effect in the corresponding stage of acute hepatitis A. The nature of this serum blocking factor in AHB is unclear.
Original language | English |
---|---|
Pages (from-to) | 145-150 |
Number of pages | 6 |
Journal | Scandinavian Journal of Clinical and Laboratory Investigation |
Volume | 56 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1996 |
Externally published | Yes |
Keywords*
- cell culture
- HBV-infection
- interferon gamma induction
- serum blocking factor
Field of Science*
- 1.4 Chemical sciences
- 1.6 Biological sciences
- 3.2 Clinical medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database