Interleukin-6 gene promoter -174G/C polymorphism and insulin resistance: A pilot study

Pēteris Tretjakovs, Gustavs Latkovskis, Normunds Licis, Dace Juhnevica, Antra Jurka, Inga Bormane, Juris I. Aivars, Agnis Stifts, Valdis Pirags

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: The aim of this pilot study was to evaluate the relationship between interleukin-6 promoter -174G/C (IL-6 -174G/C) polymorphism and insulin resistance (IR) in obese patients with coronary heart disease (CHD). Methods: Twenty obese male patients with CHD were selected from a larger database of patients (n=606). IL-6 -174G/C genotype was previously analysed and only homozygotes with the CC genotype (n=10) or GG genotype (n=10) were selected. IR was measured using the homeostasis model assessment for IR (HOMA-IR) method. Results: Differences in age, body mass index, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), hypertension, IL-6, C-reactive protein and HOMA-IR were not significant between the genotypes (p>0.05), but analysis of a homogeneity-of-slopes model showed that genotype had a significant influence on HOMA-IR (p=0.037), and the interaction between genotype and HDL-C had a pronounced tendency to affect HOMA-IR (p=0.058). Using multiple regression analysis, we found that HDL-C had a significant effect on HOMA-IR (p=0.023), and TG had a tendency to affect HOMA-IR (p=0.066) only in the CC genotype. Conclusions: Our data show that IL-6 -174G/C polymorphism may have a significant effect on IR. A comparison between the effects of various cardiovascular risk factors showed that HDL-C may have a significant effect on HOMA-IR in the CC genotype but not in the GG genotype. Further research is needed to test the preliminary results.

Original languageEnglish
Pages (from-to)1145-1148
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Volume45
Issue number9
DOIs
Publication statusPublished - 1 Sep 2007
Externally publishedYes

Keywords*

  • Adiposity
  • Coronary heart disease
  • Genotype
  • High-density lipoprotein cholesterol
  • Insulin resistance
  • Interleukin-6

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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