Invasive pneumococcal disease epidemiology in Latvia, 2017-2021

Larisa Savrasova; Indra Zeltiņa; Anita Villeruša; Angelika Krūmiņa; Hedija Čupeca; Renāte Brenča; Ilze Grope

Abstract

Objectives
Laboratory confirmed IPD cases are passively notified to the Centre for Disease Prevention and Control of Latvia (CDPC) by laboratories and clinicians.
Materials and Methods
We calculated incidence by age, sex, case fatality, and trend in serotypes by conducting a retrospective population-based study based on national IPD surveillance data.
Results
From 2017 to 2021 371 cases of IPD were reported, including 17 (4,6%) cases reported in age 0-17. The total mean IPD cases during five years are 74,2 cases per year (3,9/100,000). The highest notified incidence was in 2018 at 4.3/100,000, which fell to 3.5 in 2020. The highest mean annual IPD incidence was in infants (7.2) and in the elderly (8.0).
95% (351/371) of all S.pneumoniaein IPD cases were serotyped. PCV10 vaccine serotypes has a decreasing trend from 27% in 2017 to 17,4% in 2021. PCV13 vaccine serotypes had
an increasing trend and rose from 16,2% in 2017 to 36% in 2021 aspatially in children (aged 0-17) and elderly (aged >=65). The most common serotypes among all patients are 19A (13%, 46/351), 3 (12,8%, 45/351) and 8 (11,4%, 40/351) Total case fatality rate in study period was 16,2% (57/371) with the highest in elderly (aged >=65) 16,7% (26/155). The highest case fatality 21,4% was in 2021. 21% (12/57) of all S. pneumoniae death from IPD was associated with serotype 19A.
Conclusions
Surveillance data indicate the importance to change the vaccine in the schedule from
PCV10 to other including more S.pneumoniae serotypes.

Original language	English
Pages (from-to)	380
Number of pages	1
Journal	Medicina (Kaunas)
Volume	59
Issue number	Suppl. 2
Publication status	Published - 2023
Event	RSU Research Week 2023: Research Week 2023 Rīga Stradiņš University - Riga Stradins University, Riga, Latvia Duration: 27 Mar 2023 → 31 Mar 2023 https://rw2023.rsu.lv/general-information https://rw2023.rsu.lv

Keywords*

Pneumococcal
IPD
Streptococcus pneumoniae
Pneumonia

Field of Science*

3.3 Health sciences

Publication Type*

3.4. Other publications in conference proceedings (including local)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Invasive pneumococcal disease epidemiologyFinal published version, 102 KB

https://medicina.lsmuni.lt/abstracts-of-the-international-scientific-conferences-on-medicine-public-health-research-week-2023-riga-stradins-university-riga-latvia/

Epidemiology of Invasive Pneumococcal Disease in Latvia in 2017-2021
Savrasova, L. (Speaker), Zeltiņa, I. (Co-author), Villeruša, A. (Co-author), Krūmiņa, A. (Co-author), Čupeca, H. (Co-author), Brenča, R. (Co-author) & Grope, I. (Co-author)
30 Mar 2023
Activity: Talk or presentation types › Oral presentation

Cite this

Savrasova, L., Zeltiņa, I., Villeruša, A., Krūmiņa, A., Čupeca, H., Brenča, R., & Grope, I. (2023). Invasive pneumococcal disease epidemiology in Latvia, 2017-2021. Medicina (Kaunas), 59(Suppl. 2), 380. https://medicina.lsmuni.lt/abstracts-of-the-international-scientific-conferences-on-medicine-public-health-research-week-2023-riga-stradins-university-riga-latvia/

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title = "Invasive pneumococcal disease epidemiology in Latvia, 2017-2021",

abstract = "ObjectivesLaboratory confirmed IPD cases are passively notified to the Centre for Disease Prevention and Control of Latvia (CDPC) by laboratories and clinicians.Materials and MethodsWe calculated incidence by age, sex, case fatality, and trend in serotypes by conducting a retrospective population-based study based on national IPD surveillance data.ResultsFrom 2017 to 2021 371 cases of IPD were reported, including 17 (4,6%) cases reported in age 0-17. The total mean IPD cases during five years are 74,2 cases per year (3,9/100,000). The highest notified incidence was in 2018 at 4.3/100,000, which fell to 3.5 in 2020. The highest mean annual IPD incidence was in infants (7.2) and in the elderly (8.0).95% (351/371) of all S.pneumoniaein IPD cases were serotyped. PCV10 vaccine serotypes has a decreasing trend from 27% in 2017 to 17,4% in 2021. PCV13 vaccine serotypes had an increasing trend and rose from 16,2% in 2017 to 36% in 2021 aspatially in children (aged 0-17) and elderly (aged >=65). The most common serotypes among all patients are 19A (13%, 46/351), 3 (12,8%, 45/351) and 8 (11,4%, 40/351) Total case fatality rate in study period was 16,2% (57/371) with the highest in elderly (aged >=65) 16,7% (26/155). The highest case fatality 21,4% was in 2021. 21% (12/57) of all S. pneumoniae death from IPD was associated with serotype 19A.ConclusionsSurveillance data indicate the importance to change the vaccine in the schedule fromPCV10 to other including more S.pneumoniae serotypes.",

keywords = "Pneumococcal, IPD, Streptococcus pneumoniae, Pneumonia",

author = "Larisa Savrasova and Indra Zeltiņa and Anita Villeru{\v s}a and Angelika Krūmiņa and Hedija {\v C}upeca and Renāte Bren{\v c}a and Ilze Grope",

year = "2023",

language = "English",

volume = "59",

pages = "380",

journal = "Medicina (Kaunas)",

issn = "1010-660X",

publisher = "Kauno Medicinos Universitetas",

number = "Suppl. 2",

note = "RSU Research Week 2023 : Research Week 2023 Rīga Stradiņ{\v s} University, RW2023 ; Conference date: 27-03-2023 Through 31-03-2023",

url = "https://rw2023.rsu.lv/general-information, https://rw2023.rsu.lv",

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Savrasova, L , Zeltiņa, I , Villeruša, A , Krūmiņa, A , Čupeca, H, Brenča, R & Grope, I 2023, 'Invasive pneumococcal disease epidemiology in Latvia, 2017-2021', Medicina (Kaunas), vol. 59, no. Suppl. 2, pp. 380. <https://medicina.lsmuni.lt/abstracts-of-the-international-scientific-conferences-on-medicine-public-health-research-week-2023-riga-stradins-university-riga-latvia/>

TY - JOUR

T1 - Invasive pneumococcal disease epidemiology in Latvia, 2017-2021

AU - Savrasova, Larisa

AU - Zeltiņa, Indra

AU - Villeruša, Anita

AU - Krūmiņa, Angelika

AU - Čupeca, Hedija

AU - Brenča, Renāte

AU - Grope, Ilze

PY - 2023

Y1 - 2023

N2 - ObjectivesLaboratory confirmed IPD cases are passively notified to the Centre for Disease Prevention and Control of Latvia (CDPC) by laboratories and clinicians.Materials and MethodsWe calculated incidence by age, sex, case fatality, and trend in serotypes by conducting a retrospective population-based study based on national IPD surveillance data.ResultsFrom 2017 to 2021 371 cases of IPD were reported, including 17 (4,6%) cases reported in age 0-17. The total mean IPD cases during five years are 74,2 cases per year (3,9/100,000). The highest notified incidence was in 2018 at 4.3/100,000, which fell to 3.5 in 2020. The highest mean annual IPD incidence was in infants (7.2) and in the elderly (8.0).95% (351/371) of all S.pneumoniaein IPD cases were serotyped. PCV10 vaccine serotypes has a decreasing trend from 27% in 2017 to 17,4% in 2021. PCV13 vaccine serotypes had an increasing trend and rose from 16,2% in 2017 to 36% in 2021 aspatially in children (aged 0-17) and elderly (aged >=65). The most common serotypes among all patients are 19A (13%, 46/351), 3 (12,8%, 45/351) and 8 (11,4%, 40/351) Total case fatality rate in study period was 16,2% (57/371) with the highest in elderly (aged >=65) 16,7% (26/155). The highest case fatality 21,4% was in 2021. 21% (12/57) of all S. pneumoniae death from IPD was associated with serotype 19A.ConclusionsSurveillance data indicate the importance to change the vaccine in the schedule fromPCV10 to other including more S.pneumoniae serotypes.

AB - ObjectivesLaboratory confirmed IPD cases are passively notified to the Centre for Disease Prevention and Control of Latvia (CDPC) by laboratories and clinicians.Materials and MethodsWe calculated incidence by age, sex, case fatality, and trend in serotypes by conducting a retrospective population-based study based on national IPD surveillance data.ResultsFrom 2017 to 2021 371 cases of IPD were reported, including 17 (4,6%) cases reported in age 0-17. The total mean IPD cases during five years are 74,2 cases per year (3,9/100,000). The highest notified incidence was in 2018 at 4.3/100,000, which fell to 3.5 in 2020. The highest mean annual IPD incidence was in infants (7.2) and in the elderly (8.0).95% (351/371) of all S.pneumoniaein IPD cases were serotyped. PCV10 vaccine serotypes has a decreasing trend from 27% in 2017 to 17,4% in 2021. PCV13 vaccine serotypes had an increasing trend and rose from 16,2% in 2017 to 36% in 2021 aspatially in children (aged 0-17) and elderly (aged >=65). The most common serotypes among all patients are 19A (13%, 46/351), 3 (12,8%, 45/351) and 8 (11,4%, 40/351) Total case fatality rate in study period was 16,2% (57/371) with the highest in elderly (aged >=65) 16,7% (26/155). The highest case fatality 21,4% was in 2021. 21% (12/57) of all S. pneumoniae death from IPD was associated with serotype 19A.ConclusionsSurveillance data indicate the importance to change the vaccine in the schedule fromPCV10 to other including more S.pneumoniae serotypes.

KW - Pneumococcal

KW - IPD

KW - Streptococcus pneumoniae

KW - Pneumonia

M3 - Meeting Abstract

SN - 1010-660X

VL - 59

SP - 380

JO - Medicina (Kaunas)

JF - Medicina (Kaunas)

IS - Suppl. 2

T2 - RSU Research Week 2023

Y2 - 27 March 2023 through 31 March 2023

ER -