Involvement of the Nervous System in Systemic Sclerosis

Research output: Contribution to journalArticlepeer-review

4 Downloads (Pure)


Scleroderma is a rare heterogeneous multisystem autoimmune disease. The disease is characterized by structural abnormalities of the small blood
vessels. Scleroderma affects all organs of the body. Skin manifestations are commonly reported, but peripheral nervous system (PNS) and central
nervous system (CNS) involvement has been less frequently reported. Neurological manifestations are broad, and it is challenging for clinicians to
confirm a diagnosis of scleroderma.
Case Presentation:
In our case, a 53-year-old white woman had extensive clinical presentations: skin rashes and symptoms from internal organs, CNS, and PNS during
the previous 11 years. She had not undergone any specific treatment because diagnosis has not been made in the early stages.
It is important to make the diagnosis as early as possible and start treatment with immunomodulatory and immunosuppressant medication, as it
affects the patient's disease progression, quality of life, and mortality. A detailed medical history, physical examination, and laboratory and
radiology findings help us to identify and diagnose scleroderma. But unfortunately, it was late, and the patient died. This case guides us to be more
careful and make the diagnosis of scleroderma earlier in the future.
Original languageEnglish
Article numbere1874205X2112241
JournalOpen Neurology Journal
Publication statusPublished - Feb 2022


  • Scleroderma
  • Demyelinating
  • Nervous system
  • Immunomodulatory
  • Medications
  • Peripheral nervous system

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


Dive into the research topics of 'Involvement of the Nervous System in Systemic Sclerosis'. Together they form a unique fingerprint.

Cite this