Is abnormal vaginal microflora a risk factor for intrauterine fetal growth restriction?

Natalija Vedmedovska, Dace Rezeberga, Gilbert G.G. Donder

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
1 Downloads (Pure)


Objective: To conduct a literature review in search of possible preventable causes for fetal growth restriction. Methods: We performed a systematic literature search regarding abnormal vaginal microflora and fetal growth encompassing the last 27-year (starting from 1986) in PubMed, Embase, and Cochrane Central to study the evidence that abnormal vaginal microflora is may be related to diminished fetal growth or small for date birth. Results: Most of the 14 studies suggested a significant role of vaginal organisms in impaired fetal growth, unrelated to preterm birth. The neonatal outcome has shown to be largely linked to the preventable or foreseeable fetal factors, such as genetic abnormalities, but also ascending intrauterine infections. Our previous work suggested a role of vaginal organisms in adverse pregnancy outcome, not only preterm birth, but also impaired fetal growth. Conclusions: There is a need for cohort studies designed to unravel this link between abnormal microflora and FGR, in order to enable preventive actions to protect these small babies from severe damage and death by early screening and treatment.

Original languageEnglish
Article number25
Pages (from-to)313-316
Number of pages4
JournalAsian Pacific Journal of Reproduction
Issue number4
Publication statusPublished - 1 Dec 2015


  • Abnormal vaginal microflora
  • Bacterial vaginosis
  • Fetal growth restriction

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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